Display Settings:

Format

Send to:

Choose Destination

SHANK1 SH3 and multiple ankyrin repeat domains 1 [ Homo sapiens (human) ]

Gene ID: 50944, updated on 13-Sep-2014
Official Symbol
SHANK1provided by HGNC
Official Full Name
SH3 and multiple ankyrin repeat domains 1provided by HGNC
Primary source
HGNC:HGNC:15474
See related
Ensembl:ENSG00000161681; HPRD:05413; MIM:604999; Vega:OTTHUMG00000137380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSTRIP; SPANK-1; synamon
See SHANK1 in Epigenomics, MapViewer
Location:
19q13.3
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (50659795..50719783, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51163052..51220195, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene small ILF3/NF90-associated RNA F Neighboring gene synaptotagmin III Neighboring gene chromosome 19 open reading frame 81 Neighboring gene C-type lectin domain family 11, member A Neighboring gene G protein-coupled receptor 32, pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GKAP/Homer scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
 
SH3 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ankyrin repeat binding ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ionotropic glutamate receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein C-terminus binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
scaffold protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
somatostatin receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
adult behavior IMP
Inferred from Mutant Phenotype
more info
 
associative learning ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeletal anchoring at plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
determination of affect IMP
Inferred from Mutant Phenotype
more info
 
habituation IEA
Inferred from Electronic Annotation
more info
 
long-term memory ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular process controlling balance ISS
Inferred from Sequence or Structural Similarity
more info
 
olfactory behavior IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of excitatory postsynaptic membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
protein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
righting reflex IEA
Inferred from Electronic Annotation
more info
 
social behavior IMP
Inferred from Mutant Phenotype
more info
 
synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
vocalization behavior IMP
Inferred from Mutant Phenotype
more info
 
Component Evidence Code Pubs
colocalizes_with N-methyl-D-aspartate selective glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
dendrite NAS
Non-traceable Author Statement
more info
PubMed 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
excitatory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular NAS
Non-traceable Author Statement
more info
PubMed 
colocalizes_with ionotropic glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
SH3 and multiple ankyrin repeat domains protein 1
Names
SH3 and multiple ankyrin repeat domains protein 1
SSTR-interacting protein
somatostatin receptor-interacting protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016148.2NP_057232.2  SH3 and multiple ankyrin repeat domains protein 1

    See proteins identical to NP_057232.2

    Status: VALIDATED

    Source sequence(s)
    AC008743, AF163302
    Consensus CDS
    CCDS12799.1
    UniProtKB/Swiss-Prot
    Q9Y566
    Related
    ENSP00000293441, OTTHUMP00000174437, ENST00000293441, OTTHUMT00000268071
    Conserved Domains (6) summary
    cd09506
    Location:20942159
    Blast Score: 331
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    smart00454
    Location:20972161
    Blast Score: 163
    SAM; Sterile alpha motif
    cd11982
    Location:557608
    Blast Score: 299
    SH3_Shank1; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 1
    cd00204
    Location:274399
    Blast Score: 303
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:661754
    Blast Score: 213
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12796
    Location:318402
    Blast Score: 179
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    50659795..50719783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723233.1XP_006723296.1  

    See proteins identical to XP_006723296.1

    UniProtKB/Swiss-Prot
    Q9Y566
    Conserved Domains (6) summary
    cd09506
    Location:20942159
    Blast Score: 331
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    smart00454
    Location:20972161
    Blast Score: 163
    SAM; Sterile alpha motif
    cd11982
    Location:557608
    Blast Score: 299
    SH3_Shank1; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 1
    cd00204
    Location:274399
    Blast Score: 303
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:661754
    Blast Score: 213
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12796
    Location:318402
    Blast Score: 179
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_006723234.1XP_006723297.1  

    UniProtKB/Swiss-Prot
    Q9Y566
    Conserved Domains (6) summary
    cd09506
    Location:20852150
    Blast Score: 331
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    smart00454
    Location:20882152
    Blast Score: 163
    SAM; Sterile alpha motif
    cd11982
    Location:557608
    Blast Score: 300
    SH3_Shank1; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 1
    cd00204
    Location:274399
    Blast Score: 303
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:652745
    Blast Score: 213
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12796
    Location:318402
    Blast Score: 179
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_005258963.1XP_005259020.1  

    UniProtKB/TrEMBL
    H9KV90
    Conserved Domains (6) summary
    cd09506
    Location:21022167
    Blast Score: 331
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    smart00454
    Location:21052169
    Blast Score: 163
    SAM; Sterile alpha motif
    cd11982
    Location:557608
    Blast Score: 299
    SH3_Shank1; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 1
    cd00204
    Location:274399
    Blast Score: 303
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:661754
    Blast Score: 213
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12796
    Location:318402
    Blast Score: 179
    Ank_2; Ankyrin repeats (3 copies)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    47499910..47555290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    51166866..51221938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)