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    EPHB2 EPH receptor B2 [ Homo sapiens (human) ]

    Gene ID: 2048, updated on 24-Aug-2015
    Official Symbol
    EPHB2provided by HGNC
    Official Full Name
    EPH receptor B2provided by HGNC
    Primary source
    HGNC:HGNC:3393
    See related
    HPRD:02997; MIM:600997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5
    Summary
    This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
    Orthologs
    See EPHB2 in Epigenomics, MapViewer
    Location:
    1p36.1-p35
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (22710770..22915330)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23037263..23241823)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene complement component 1, q subcomponent, C chain Neighboring gene complement component 1, q subcomponent, B chain Neighboring gene microRNA 4684 Neighboring gene uncharacterized LOC105376857 Neighboring gene microRNA 4253 Neighboring gene lactamase, beta-like 1 Neighboring gene chromosome 1 open reading frame 234

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of EPH receptor B2 (EPHB2) in peptide-treated PBMCs PubMed
    Nef nef HIV-1 Nef rapidly terminates ERK activation in the presence of TPA in a macrophage-inducing system PubMed

    Go to the HIV-1, Human Interaction Database

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
      EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
    • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
      EPH-ephrin mediated repulsion of cells, organism-specific biosystemDespite high-affinity multimeric interaction between EPHs and ephrins (EFNs), the cellular response to EPH-EFN engagement is usually repulsion between the two cells and signal termination. These repu...
    • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHB forward signaling, organism-specific biosystem
      EPHB forward signaling
    • EPHB-mediated forward signaling, organism-specific biosystem (from REACTOME)
      EPHB-mediated forward signaling, organism-specific biosystemMultiple EPHB receptors contribute directly to dendritic spine development and morphogenesis. These are more broadly involved in post-synaptic development through activation of focal adhesion kinase ...
    • Ephrin B reverse signaling, organism-specific biosystem (from Pathway Interaction Database)
      Ephrin B reverse signaling, organism-specific biosystem
      Ephrin B reverse signaling
    • Ephrin signaling, organism-specific biosystem (from REACTOME)
      Ephrin signaling, organism-specific biosystemThe interaction between ephrin (EFN) ligands and EPH receptors results not only in forward signaling through the EPH receptor, but also in 'reverse' signaling through the EFN ligand itself. Reverse s...
    • EphrinB-EPHB pathway, organism-specific biosystem (from Pathway Interaction Database)
      EphrinB-EPHB pathway, organism-specific biosystem
      EphrinB-EPHB pathway
    • Keap1-Nrf2 Pathway, organism-specific biosystem (from WikiPathways)
      Keap1-Nrf2 Pathway, organism-specific biosystemBased on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4].
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • MAP kinase cascade, organism-specific biosystem (from BIOCYC)
      MAP kinase cascade, organism-specific biosystemThe MAP kinase cascade describes a sequence of phosphorylation events involving serine/threonine-specific protein kinases. Used by various signal transduction pathways, this cascade constitutes a com...
    • NLR proteins, organism-specific biosystem (from WikiPathways)
      NLR proteins, organism-specific biosystemMammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular- patterns (PAMP...
    • Regulation of Microtubule Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Microtubule Cytoskeleton, organism-specific biosystem
      Regulation of Microtubule Cytoskeleton
    • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-2-mediated signaling events, organism-specific biosystem
      Syndecan-2-mediated signaling events
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC87492

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    axon guidance receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane-ephrin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transmembrane-ephrin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon guidance TAS
    Traceable Author Statement
    more info
     
    axonal fasciculation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    camera-type eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system projection neuron axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    commissural neuron axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    corpus callosum development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    inner ear morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    learning IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    optic nerve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    palate development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of long-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of body fluid levels ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    retinal ganglion cell axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    urogenital system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    ephrin type-B receptor 2
    Names
    EPH-like kinase 5
    developmentally-regulated Eph-related tyrosine kinase
    elk-related tyrosine kinase
    eph tyrosine kinase 3
    protein-tyrosine kinase HEK5
    renal carcinoma antigen NY-REN-47
    tyrosine-protein kinase TYRO5
    tyrosine-protein kinase receptor EPH-3
    NP_004433.2
    NP_059145.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011804.2 RefSeqGene

      Range
      5001..215663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_780

    mRNA and Protein(s)

    1. NM_001309192.1NP_001296121.1  ephrin type-B receptor 2 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region compared to variant 2. It encodes isoform 3, which is shorter than isoform 2.
      Source sequence(s)
      AB210018, AK025975, AK125423, AK299701, AL035704, BC007903, BC018763, BC067861, CA417154, DB282024
    2. NM_001309193.1NP_001296122.1  ephrin type-B receptor 2 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001296122.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site at an internal exon and alternate splice sites in the 3' coding region and 3' UTR, which results in a longer and novel 3' coding region compared to variant 2. It encodes isoform 4, which is longer than and has a distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AB210018, AF025304, AK025975, AK125423, AL035704, BC067861, CA417154, DB282024
      Conserved Domains (9) summary
      cd05065
      Location:616884
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:910980
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:910977
      SAM; Sterile alpha motif
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      cd00063
      Location:436527
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07714
      Location:621880
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:543617
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cd00185
      Location:272303
      TNFRSF; CRD2 [structural motif]
      cl22855
      Location:252378
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    3. NM_004442.7NP_004433.2  ephrin type-B receptor 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_004433.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. It encodes isoform 2.
      Source sequence(s)
      AB210018, AK025975, AK125423, AL035704, BC067861, CA417154, DB282024, L41939
      Consensus CDS
      CCDS230.1
      UniProtKB/Swiss-Prot
      P29323
      Conserved Domains (9) summary
      cd05065
      Location:617885
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:911981
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:911978
      SAM; Sterile alpha motif
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      cd00063
      Location:436527
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07714
      Location:622881
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:543618
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cd00185
      Location:272303
      TNFRSF; CRD2 [structural motif]
      cl22855
      Location:252378
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    4. NM_017449.4NP_059145.2  ephrin type-B receptor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_059145.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site compared to variant 2. It encodes isoform 1, which is shorter than isoform 2.
      Source sequence(s)
      AB210018, AF025304, AK025975, AK125423, AL035704, BC067861, CA417154, DB282024
      Consensus CDS
      CCDS229.2
      UniProtKB/Swiss-Prot
      P29323
      Conserved Domains (9) summary
      cd05065
      Location:616884
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:910980
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:910977
      SAM; Sterile alpha motif
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      cd00063
      Location:436527
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07714
      Location:621880
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:543617
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cd00185
      Location:272303
      TNFRSF; CRD2 [structural motif]
      cl22855
      Location:252378
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      22710770..22915330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006710442.2XP_006710505.1  

      Conserved Domains (9) summary
      cd05065
      Location:586854
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:880950
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:880947
      SAM; Sterile alpha motif
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      cd00063
      Location:325431
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07714
      Location:591850
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:512587
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cd00185
      Location:272303
      TNFRSF; CRD2 [structural motif]
      cl22855
      Location:252378
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    2. XM_006710441.2XP_006710504.1  

      Conserved Domains (9) summary
      cd05065
      Location:610878
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:904974
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:904971
      SAM; Sterile alpha motif
      cd10477
      Location:12189
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      cd00063
      Location:429520
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07714
      Location:615874
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:536611
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cd00185
      Location:265296
      TNFRSF; CRD2 [structural motif]
      cl22855
      Location:245371
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    3. XM_011540976.1XP_011539278.1  

      See identical proteins and their annotated locations for XP_011539278.1

      Conserved Domains (6) summary
      cd05065
      Location:175443
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:469539
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:469536
      SAM; Sterile alpha motif
      cd00063
      Location:786
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07714
      Location:180439
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:102176
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      23149831..23354155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)