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Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 [ Mus musculus (house mouse) ]

Gene ID: 18140, updated on 26-Aug-2014
Official Symbol
Uhrf1provided by MGI
Official Full Name
ubiquitin-like, containing PHD and RING finger domains, 1provided by MGI
Primary source
MGI:1338889
See related
Ensembl:ENSMUSG00000001228; Vega:OTTMUSG00000021035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Np95; ICBP90; RNF106; AL022808
See Uhrf1 in Epigenomics, MapViewer
Location:
17; 17 D-E1
Exon count:
18
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 17 NC_000083.6 (56303337..56323486)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene perilipin 3 Neighboring gene arrestin domain containing 5 Neighboring gene lysine (K)-specific demethylase 4B Neighboring gene uncharacterized LOC102635354 Neighboring gene protein tyrosine phosphatase, receptor type, S Neighboring gene microRNA mir-6977

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-0 gamma-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-2 alpha-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
hemi-methylated DNA-binding IDA
Inferred from Direct Assay
more info
PubMed 
hemi-methylated DNA-binding ISO
Inferred from Sequence Orthology
more info
 
histone binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
 
methylated histone binding IDA
Inferred from Direct Assay
more info
 
methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
nucleosomal histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, elongating IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, initiating IEA
Inferred from Electronic Annotation
more info
 
ribosomal S6-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
histone monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
histone ubiquitination ISO
Inferred from Sequence Orthology
more info
 
maintenance of DNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of DNA methylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
euchromatin ISO
Inferred from Sequence Orthology
more info
 
heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
heterochromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
replication fork IDA
Inferred from Direct Assay
more info
PubMed 
replication fork ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
E3 ubiquitin-protein ligase UHRF1
Names
E3 ubiquitin-protein ligase UHRF1
mUhrf1
nuclear protein 95
nuclear zinc finger protein Np95
ubiquitin-like PHD and RING finger domain-containing protein 1
ubiquitin-like-containing PHD and RING finger domains protein 1
NP_001104548.1
NP_001104549.1
NP_001104550.1
NP_035061.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111078.1NP_001104548.1  E3 ubiquitin-protein ligase UHRF1 isoform A

    See proteins identical to NP_001104548.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode isoform (A).
    Source sequence(s)
    AF274046, AK143688, AK150489
    Consensus CDS
    CCDS28903.1
    UniProtKB/Swiss-Prot
    Q8VDF2
    Related
    ENSMUSP00000108662, OTTMUSP00000023100, ENSMUST00000113039, OTTMUST00000049739
    Conserved Domains (5) summary
    pfam12148
    Location:136232
    Blast Score: 383
    DUF3590; Protein of unknown function (DUF3590)
    cd01797
    Location:178
    Blast Score: 407
    NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
    smart00466
    Location:419590
    Blast Score: 601
    SRA; SET and RING finger associated domain
    cd00162
    Location:713755
    Blast Score: 115
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00628
    Location:323369
    Blast Score: 167
    PHD; PHD-finger
  2. NM_001111079.1NP_001104549.1  E3 ubiquitin-protein ligase UHRF1 isoform B

    See proteins identical to NP_001104549.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform B). Variants 3 and 4 encode isoform B.
    Source sequence(s)
    AF274046, AK147046, BY140812
    Consensus CDS
    CCDS50151.1
    UniProtKB/Swiss-Prot
    Q8VDF2
    Related
    ENSMUSP00000108661, OTTMUSP00000023098, ENSMUST00000113038, OTTMUST00000049737
    Conserved Domains (5) summary
    pfam12148
    Location:136232
    Blast Score: 383
    DUF3590; Protein of unknown function (DUF3590)
    cd01797
    Location:178
    Blast Score: 406
    NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
    smart00466
    Location:411582
    Blast Score: 600
    SRA; SET and RING finger associated domain
    cd00162
    Location:705747
    Blast Score: 115
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00628
    Location:315361
    Blast Score: 167
    PHD; PHD-finger
  3. NM_001111080.1NP_001104550.1  E3 ubiquitin-protein ligase UHRF1 isoform B

    See proteins identical to NP_001104550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region and differs in the 5' UTR, compared to variant 1, resulting in a shorter protein (isoform B). Variants 3 and 4 encode isoform B.
    Source sequence(s)
    AF274046, AK147046, AK150489
    Consensus CDS
    CCDS50151.1
    UniProtKB/Swiss-Prot
    Q8VDF2
    Related
    ENSMUSP00000108658, OTTMUSP00000023099, ENSMUST00000113035, OTTMUST00000049738
    Conserved Domains (5) summary
    pfam12148
    Location:136232
    Blast Score: 383
    DUF3590; Protein of unknown function (DUF3590)
    cd01797
    Location:178
    Blast Score: 406
    NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
    smart00466
    Location:411582
    Blast Score: 600
    SRA; SET and RING finger associated domain
    cd00162
    Location:705747
    Blast Score: 115
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00628
    Location:315361
    Blast Score: 167
    PHD; PHD-finger
  4. NM_010931.3NP_035061.3  E3 ubiquitin-protein ligase UHRF1 isoform A

    See proteins identical to NP_035061.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A). Variants 1 and 2 encode isoform (A).
    Source sequence(s)
    AF274046, AK145543, BY140812
    Consensus CDS
    CCDS28903.1
    UniProtKB/Swiss-Prot
    Q8VDF2
    Related
    ENSMUSP00000001258, OTTMUSP00000023097, ENSMUST00000001258, OTTMUST00000049736
    Conserved Domains (5) summary
    pfam12148
    Location:136232
    Blast Score: 383
    DUF3590; Protein of unknown function (DUF3590)
    cd01797
    Location:178
    Blast Score: 407
    NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
    smart00466
    Location:419590
    Blast Score: 601
    SRA; SET and RING finger associated domain
    cd00162
    Location:713755
    Blast Score: 115
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00628
    Location:323369
    Blast Score: 167
    PHD; PHD-finger

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000083.6 

    Range
    56303337..56323486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523799.1XP_006523862.1  

    Conserved Domains (5) summary
    pfam12148
    Location:136229
    Blast Score: 343
    DUF3590; Protein of unknown function (DUF3590)
    cd01797
    Location:178
    Blast Score: 408
    NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
    smart00466
    Location:416587
    Blast Score: 601
    SRA; SET and RING finger associated domain
    cd00162
    Location:710752
    Blast Score: 115
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00628
    Location:320366
    Blast Score: 168
    PHD; PHD-finger
  2. XM_006523800.1XP_006523863.1  

    Conserved Domains (5) summary
    pfam12148
    Location:136229
    Blast Score: 343
    DUF3590; Protein of unknown function (DUF3590)
    cd01797
    Location:178
    Blast Score: 407
    NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
    smart00466
    Location:408579
    Blast Score: 600
    SRA; SET and RING finger associated domain
    cd00162
    Location:702744
    Blast Score: 115
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00628
    Location:312358
    Blast Score: 167
    PHD; PHD-finger

Alternate Mm_Celera

Genomic

  1. AC_000039.1 

    Range
    60657174..60672221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)