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MYB v-myb avian myeloblastosis viral oncogene homolog [ Homo sapiens (human) ]

Gene ID: 4602, updated on 5-Apr-2015
Official Symbol
MYBprovided by HGNC
Official Full Name
v-myb avian myeloblastosis viral oncogene homologprovided by HGNC
Primary source
HGNC:HGNC:7545
See related
Ensembl:ENSG00000118513; HPRD:01810; MIM:189990; Vega:OTTHUMG00000015629
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
efg; Cmyb; c-myb; c-myb_CDS
Summary
This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Orthologs
See MYB in MapViewer
Location:
6q22-q23
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (135180981..135219173)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (135502453..135540311)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene HBS1-like translational GTPase Neighboring gene microRNA 3662 Neighboring gene uncharacterized LOC105378010 Neighboring gene uncharacterized LOC105378011 Neighboring gene microRNA 548a-2 Neighboring gene Abelson helper integration site 1 Neighboring gene beta-transducin repeat containing E3 ubiquitin protein ligase pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
NHGRI GWA Catalog
A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E.
NHGRI GWA Catalog
A genome-wide association study of red blood cell traits using the electronic medical record.
NHGRI GWA Catalog
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
NHGRI GWA Catalog
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
NHGRI GWA Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog
GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
NHGRI GWA Catalog
HbA2 levels in normal adults are influenced by two distinct genetic mechanisms.
NHGRI GWA Catalog
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
NHGRI GWA Catalog
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
NHGRI GWA Catalog
Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
NHGRI GWA Catalog
New gene functions in megakaryopoiesis and platelet formation.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Sequence variants in three loci influence monocyte counts and erythrocyte volume.
NHGRI GWA Catalog
Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma.
NHGRI GWA Catalog
  • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    C-MYB transcription factor network, organism-specific biosystem
    C-MYB transcription factor network
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • IL2 signaling events mediated by PI3K, organism-specific biosystem (from Pathway Interaction Database)
    IL2 signaling events mediated by PI3K, organism-specific biosystem
    IL2 signaling events mediated by PI3K
  • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL4-mediated signaling events, organism-specific biosystem
    IL4-mediated signaling events
  • Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
    Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...
  • Notch-mediated HES/HEY network, organism-specific biosystem (from Pathway Interaction Database)
    Notch-mediated HES/HEY network, organism-specific biosystem
    Notch-mediated HES/HEY network
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-6 IEA
Inferred from Electronic Annotation
more info
 
chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digestive tract development IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T-helper cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone H3-K4 methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone H3-K9 methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
thymus development IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
transcriptional activator Myb
Names
transcriptional activator Myb
c-myb protein (140 AA)
c-myb10A_CDS
c-myb13A_CDS
c-myb14A_CDS
c-myb8B_CDS
proto-oncogene c-Myb

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012330.1 RefSeqGene

    Range
    5001..42859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130172.1NP_001123644.1  transcriptional activator Myb isoform 3

    See proteins identical to NP_001123644.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal segment and an exon in the coding region, as compared to variant 1. The reading frame is not affected, so the resulting isoform (3) lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AJ606320, D25774
    Consensus CDS
    CCDS47482.1
    UniProtKB/Swiss-Prot
    P10242
    Related
    ENSP00000410825, OTTHUMP00000234321, ENST00000442647, OTTHUMT00000391709
    Conserved Domains (3) summary
    pfam07988
    Location:266313
    LMSTEN; LMSTEN motif
    cd00167
    Location:94138
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The ...
    pfam09316
    Location:399564
    Cmyb_C; C-myb, C-terminal
  2. NM_001130173.1NP_001123645.1  transcriptional activator Myb isoform 1

    See proteins identical to NP_001123645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AJ606319, D25774
    Consensus CDS
    CCDS47481.1
    UniProtKB/Swiss-Prot
    P10242
    Related
    ENSP00000339992, OTTHUMP00000017259, ENST00000341911, OTTHUMT00000042348
    Conserved Domains (3) summary
    pfam07988
    Location:266313
    LMSTEN; LMSTEN motif
    cd00167
    Location:94138
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The ...
    pfam09316
    Location:518688
    Cmyb_C; C-myb, C-terminal
  3. NM_001161656.1NP_001155128.1  transcriptional activator Myb isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 4) compared to isoform 1.
    Source sequence(s)
    AL023693
    Consensus CDS
    CCDS55058.1
    UniProtKB/Swiss-Prot
    P10242
    Conserved Domains (3) summary
    pfam07988
    Location:266313
    LMSTEN; LMSTEN motif
    cd00167
    Location:94138
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The ...
    pfam09316
    Location:515685
    Cmyb_C; C-myb, C-terminal
  4. NM_001161657.1NP_001155129.1  transcriptional activator Myb isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame segments in the coding region, as compared to variant 1. This variant encodes isoform 5, which is shorter than isoform 1.
    Source sequence(s)
    AL023693
    Consensus CDS
    CCDS55061.1
    UniProtKB/Swiss-Prot
    P10242
    Related
    ENSP00000435938, OTTHUMP00000234322, ENST00000525369, OTTHUMT00000391710
    Conserved Domains (3) summary
    pfam07988
    Location:266313
    LMSTEN; LMSTEN motif
    cd00167
    Location:94138
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The ...
    pfam09316
    Location:317482
    Cmyb_C; C-myb, C-terminal
  5. NM_001161658.1NP_001155130.1  transcriptional activator Myb isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 6) compared to isoform 1.
    Source sequence(s)
    AL023693
    Consensus CDS
    CCDS55059.1
    UniProtKB/Swiss-Prot
    P10242
    Conserved Domains (3) summary
    pfam07988
    Location:266313
    LMSTEN; LMSTEN motif
    cd00167
    Location:94138
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The ...
    pfam09316
    Location:502672
    Cmyb_C; C-myb, C-terminal
  6. NM_001161659.1NP_001155131.1  transcriptional activator Myb isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two alternate in-frame segments in the coding region, as compared to variant 1. This variant encodes isoform 7, which is shorter than isoform 1.
    Source sequence(s)
    AL023693
    Consensus CDS
    CCDS55060.1
    UniProtKB/Swiss-Prot
    P10242
    Conserved Domains (3) summary
    pfam07988
    Location:266313
    LMSTEN; LMSTEN motif
    cd00167
    Location:94138
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The ...
    pfam09316
    Location:402594
    Cmyb_C; C-myb, C-terminal
  7. NM_001161660.1NP_001155132.1  transcriptional activator Myb isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks two alternate in-frame segments in the coding region, as compared to variant 1. This variant encodes isoform 8, which is shorter than isoform 1.
    Source sequence(s)
    AL023693
    Consensus CDS
    CCDS55062.1
    UniProtKB/Swiss-Prot
    P10242
    Conserved Domains (2) summary
    cd00167
    Location:94138
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The ...
    pfam09316
    Location:367532
    Cmyb_C; C-myb, C-terminal
  8. NM_005375.2NP_005366.2  transcriptional activator Myb isoform 2

    See proteins identical to NP_005366.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC035996, BC064955, X52125, X52126
    Consensus CDS
    CCDS5174.1
    UniProtKB/Swiss-Prot
    P10242
    UniProtKB/TrEMBL
    Q14025
    UniProtKB/TrEMBL
    Q708E9
    Related
    ENSP00000356788, OTTHUMP00000017258, ENST00000367814, OTTHUMT00000042347
    Conserved Domains (3) summary
    pfam07988
    Location:266313
    LMSTEN; LMSTEN motif
    cd00167
    Location:94138
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The ...
    pfam09316
    Location:402567
    Cmyb_C; C-myb, C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    135180981..135219173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_942446.1 RNA Sequence

  2. XR_942445.1 RNA Sequence

  3. XR_942443.1 RNA Sequence

  4. XR_942444.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    135764731..135802560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)