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    B4GALT4 beta-1,4-galactosyltransferase 4 [ Homo sapiens (human) ]

    Gene ID: 8702, updated on 15-Jun-2016
    Official Symbol
    B4GALT4provided by HGNC
    Official Full Name
    beta-1,4-galactosyltransferase 4provided by HGNC
    Primary source
    HGNC:HGNC:927
    See related
    Ensembl:ENSG00000121578 HPRD:04930; MIM:604015; Vega:OTTHUMG00000159358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B4Gal-T4; beta4Gal-T4
    Summary
    This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    3q13.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (119211742..119240946, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (118930589..118959754, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene chromosome 3 open reading frame 30 Neighboring gene uroplakin 1B Neighboring gene B4GALT4 antisense RNA 1 Neighboring gene Rho GTPase activating protein 31 Neighboring gene ribosomal protein S26 pseudogene 21 Neighboring gene ARHGAP31 antisense RNA 1

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N-acetyllactosamine synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity TAS
    Traceable Author Statement
    more info
     
    galactosyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    keratan sulfate biosynthetic process TAS
    Traceable Author Statement
    more info
     
    membrane lipid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    beta-1,4-galactosyltransferase 4
    Names
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4
    UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 4
    UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4
    beta-1,4-GalTase 4
    beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 4
    NP_003769.1
    NP_997708.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003778.3NP_003769.1  beta-1,4-galactosyltransferase 4

      See identical proteins and their annotated locations for NP_003769.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR, as compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF038662, AK001006, AK123182, AU099090, BC062618, BX647468
      Consensus CDS
      CCDS2986.1
      UniProtKB/Swiss-Prot
      O60513
      UniProtKB/TrEMBL
      B2RAZ5, B3KM35
      Related
      ENSP00000377360, OTTHUMP00000215078, ENST00000393765, OTTHUMT00000354979
      Conserved Domains (1) summary
      cd00899
      Location:122339
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    2. NM_212543.1NP_997708.1  beta-1,4-galactosyltransferase 4

      See identical proteins and their annotated locations for NP_997708.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AF038662, AK001006, AK123182, AU099090, BC062618
      Consensus CDS
      CCDS2986.1
      UniProtKB/Swiss-Prot
      O60513
      UniProtKB/TrEMBL
      B2RAZ5, B3KM35
      Related
      ENSP00000352144, OTTHUMP00000215050, ENST00000359213, OTTHUMT00000354926
      Conserved Domains (1) summary
      cd00899
      Location:122339
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      119211742..119240946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007401.1XP_016862890.1  

    2. XM_011513260.1XP_011511562.1  

      See identical proteins and their annotated locations for XP_011511562.1

      UniProtKB/Swiss-Prot
      O60513
      UniProtKB/TrEMBL
      B2RAZ5
      Conserved Domains (1) summary
      cd00899
      Location:122339
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    3. XM_006713798.2XP_006713861.1  

      See identical proteins and their annotated locations for XP_006713861.1

      UniProtKB/Swiss-Prot
      O60513
      UniProtKB/TrEMBL
      B2RAZ5
      Conserved Domains (1) summary
      cd00899
      Location:122339
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    4. XM_006713801.2XP_006713864.1  

      See identical proteins and their annotated locations for XP_006713864.1

      UniProtKB/Swiss-Prot
      O60513
      UniProtKB/TrEMBL
      B2RAZ5
      Conserved Domains (1) summary
      cd00899
      Location:122339
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    5. XM_006713799.2XP_006713862.1  

      See identical proteins and their annotated locations for XP_006713862.1

      UniProtKB/Swiss-Prot
      O60513
      UniProtKB/TrEMBL
      B2RAZ5
      Conserved Domains (1) summary
      cd00899
      Location:122339
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    6. XM_005247855.1XP_005247912.1  

      See identical proteins and their annotated locations for XP_005247912.1

      UniProtKB/Swiss-Prot
      O60513
      UniProtKB/TrEMBL
      B2RAZ5
      Conserved Domains (1) summary
      cd00899
      Location:122339
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    7. XM_006713800.1XP_006713863.1  

      See identical proteins and their annotated locations for XP_006713863.1

      UniProtKB/Swiss-Prot
      O60513
      UniProtKB/TrEMBL
      B2RAZ5
      Related
      ENSP00000420161, OTTHUMP00000215049, ENST00000483209, OTTHUMT00000354925
      Conserved Domains (1) summary
      cd00899
      Location:122339
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RNA

    1. XR_001740342.1 RNA Sequence

    2. XR_001740346.1 RNA Sequence

    3. XR_001740344.1 RNA Sequence

    4. XR_001740340.1 RNA Sequence

      Related
      ENST00000480814, OTTHUMT00000354980
    5. XR_001740345.1 RNA Sequence

    6. XR_001740343.1 RNA Sequence

    7. XR_001740341.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      118894016..118923181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)