Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 [ Homo sapiens (human) ]

Gene ID: 8740, updated on 6-Jul-2014
Official Symbol
TNFSF14provided by HGNC
Official Full Name
tumor necrosis factor (ligand) superfamily, member 14provided by HGNC
Primary source
HGNC:11930
Locus tag
UNQ391/PRO726
See related
Ensembl:ENSG00000125735; HPRD:05157; MIM:604520; Vega:OTTHUMG00000181835
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LTg; TR2; CD258; HVEML; LIGHT
Summary
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
See TNFSF14 in Epigenomics, MapViewer
Location:
19p13.3
Exon count :
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (6661253..6670588, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6661264..6670599, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CD70 molecule Neighboring gene ribosomal protein L7 pseudogene 50 Neighboring gene complement component 3 Neighboring gene G protein-coupled receptor 108 Neighboring gene microRNA 6791

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Nef, p27 nef Expression of HIV-1 Nef in a CD4+ human T-cell hybridoma enhances the surface levels of the membrane-bound cytokines tumor necrosis factor (TNF) and LIGHT; the enhancement of TNF and LIGHT depends on the presence of a functional dileucine motif in Nef PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell activation NAS
Non-traceable Author Statement
more info
PubMed 
T cell costimulation IEA
Inferred from Electronic Annotation
more info
 
T cell homeostasis NAS
Non-traceable Author Statement
more info
PubMed 
T cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
release of cytoplasmic sequestered NF-kappaB IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tumor necrosis factor ligand superfamily member 14
Names
tumor necrosis factor ligand superfamily member 14
delta transmembrane LIGHT
herpesvirus entry mediator A
herpesvirus entry mediator ligand
herpesvirus entry mediator-ligand
herpes virus entry mediator ligand
ligand for herpesvirus entry mediator
tumor necrosis factor receptor-like 2
tumor necrosis factor superfamily member LIGHT

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003807.3NP_003798.2  tumor necrosis factor ligand superfamily member 14 isoform 1 precursor

    See proteins identical to NP_003798.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a longer isoform (1).
    Source sequence(s)
    AC008760, AF064090, AY358812
    Consensus CDS
    CCDS12171.1
    UniProtKB/Swiss-Prot
    O43557
    Conserved Domains (1) summary
    cd00184
    Location:94238
    Blast Score: 342
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
  2. NM_172014.2NP_742011.2  tumor necrosis factor ligand superfamily member 14 isoform 2

    See proteins identical to NP_742011.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding segment compared to variant 1, resulting an isoform (2) that lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    AC008760, AF064090, AY028261
    Consensus CDS
    CCDS45939.1
    UniProtKB/Swiss-Prot
    O43557
    Related
    ENSP00000326940, ENST00000326176
    Conserved Domains (1) summary
    cd00184
    Location:58202
    Blast Score: 344
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    6661253..6670588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259670.1XP_005259727.1  

    See proteins identical to XP_005259727.1

    UniProtKB/Swiss-Prot
    O43557
    Conserved Domains (1) summary
    cd00184
    Location:58202
    Blast Score: 344
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    6425122..6432649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    6663409..6670848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...