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    Syk spleen tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 20963, updated on 25-Aug-2016
    Official Symbol
    Sykprovided by MGI
    Official Full Name
    spleen tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:99515
    See related
    Ensembl:ENSMUSG00000021457 Vega:OTTMUSG00000031741
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sykb
    Orthologs
    Location:
    13 27.41 cM; 13 B-C2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (52582329..52648792)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (52692251..52744161)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33168 Neighboring gene predicted gene 2848 Neighboring gene expressed sequence BB123696 Neighboring gene predicted gene, 33315 Neighboring gene AU RNA binding protein/enoyl-coenzyme A hydratase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (13)  1 citation
    • Chemically induced (ENU) (2) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Toll-like receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor signaling protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    activation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of MAPK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of MAPK activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    beta selection IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to low-density lipoprotein particle stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to molecule of fungal origin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enzyme linked receptor protein signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukocyte activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    leukotriene biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymph vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    macrophage activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of alpha-beta T cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of alpha-beta T cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytokine secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of gamma-delta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-3 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of type I interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of arachidonic acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neutrophil degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of superoxide anion generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    serotonin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    serotonin secretion by platelet IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription factor import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    B cell receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    early phagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    tyrosine-protein kinase SYK
    NP_001185906.1
    NP_035648.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198977.1NP_001185906.1  tyrosine-protein kinase SYK

      See identical proteins and their annotated locations for NP_001185906.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK049207, BC065121
      Consensus CDS
      CCDS26517.1
      UniProtKB/Swiss-Prot
      P48025
      UniProtKB/TrEMBL
      Q3UPF7, Q6P1E0
      Related
      ENSMUSP00000113852, OTTMUSP00000041830, ENSMUST00000120135, OTTMUST00000078613
      Conserved Domains (4) summary
      cd05116
      Location:370625
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:368620
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_011518.2NP_035648.2  tyrosine-protein kinase SYK

      See identical proteins and their annotated locations for NP_035648.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BB629720, BC065121, U36776
      Consensus CDS
      CCDS26517.1
      UniProtKB/Swiss-Prot
      P48025
      UniProtKB/TrEMBL
      Q3UPF7, Q6P1E0
      Related
      ENSMUSP00000060828, OTTMUSP00000041831, ENSMUST00000055087, OTTMUST00000078614
      Conserved Domains (4) summary
      cd05116
      Location:370625
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:368620
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      52582329..52648792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516895.3XP_006516958.1  

      See identical proteins and their annotated locations for XP_006516958.1

      UniProtKB/Swiss-Prot
      P48025
      UniProtKB/TrEMBL
      Q3UPF7
      Conserved Domains (4) summary
      cd05116
      Location:370625
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:368620
      Pkinase_Tyr; Protein tyrosine kinase
    2. XM_006516897.3XP_006516960.1  

      See identical proteins and their annotated locations for XP_006516960.1

      Related
      ENSMUSP00000112914, OTTMUSP00000041832, ENSMUST00000118756, OTTMUST00000078615
      Conserved Domains (4) summary
      cd05116
      Location:347602
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:347597
      Pkinase_Tyr; Protein tyrosine kinase
    3. XM_017315470.1XP_017170959.1  

    4. XM_006516896.3XP_006516959.1  

      See identical proteins and their annotated locations for XP_006516959.1

      Conserved Domains (4) summary
      cd05116
      Location:347602
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:347597
      Pkinase_Tyr; Protein tyrosine kinase
    5. XM_017315471.1XP_017170960.1