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    bioD dethiobiotin synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945387, updated on 4-May-2016
    Gene symbol
    bioD
    Gene description
    dethiobiotin synthetase
    Primary source
    EcoGene:EG10120
    Locus tag
    b0778
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0767; JW0761
    Summary
    False positive lipoprotein prediction, verified amino terminus, Met is cleaved. [More information is available at EcoGene: EG10120]. Dethiobiotin synthetase catalyzes the first ring closure in the biosynthesis of biotin, which is the penultimate step in the biosynthesis pathway. [More information is available at EcoCyc: EG10120].
    Sequence:
    NC_000913.3 (812270..812947)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 7,8-diaminopelargonic acid synthase, PLP-dependent Neighboring gene biotin synthase Neighboring gene 8-amino-7-oxononanoate synthase Neighboring gene malonyl-ACP O-methyltransferase, SAM-dependent Neighboring gene exision nuclease of nucleotide excision repair, DNA damage recognition component Neighboring gene putative CofD superfamily transferase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      812270..812947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415299.1 dethiobiotin synthetase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415299.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P13000
      Conserved Domains (2) summary
      cd03109
      Location:3205
      DTBS; Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and ...
      pfam13500
      Location:3209
      AAA_26; AAA domain