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Ctsl cathepsin L [ Mus musculus (house mouse) ]

Gene ID: 13039, updated on 9-May-2015
Official Symbol
Ctslprovided by MGI
Official Full Name
cathepsin Lprovided by MGI
Primary source
MGI:MGI:88564
See related
Ensembl:ENSMUSG00000021477
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
fs; MEP; nkt; Ctsl1; 1190035F06Rik
Orthologs
See Ctsl in MapViewer
Location:
13 B3; 13 33.26 cM
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (64363214..64370883, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (64464522..64471614, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene AhpC/TSA antioxidant enzyme domain containing 1 Neighboring gene predicted gene, 31128 Neighboring gene RIKEN cDNA 1700015C15 gene Neighboring gene cyclin-dependent kinase 20 Neighboring gene predicted gene, 31218 Neighboring gene BTB (POZ) domain containing 3 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
cysteine-type carboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
kininogen binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
catagen IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell communication ISO
Inferred from Sequence Orthology
more info
 
decidualization IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT epithelial tube branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autoprocessing IDA
Inferred from Direct Assay
more info
PubMed 
protein processing IDA
Inferred from Direct Assay
more info
PubMed 
protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
proteolysis involved in cellular protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of actin cytoskeleton reorganization IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with apical part of cell ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosome ISO
Inferred from Sequence Orthology
more info
 
microvillus ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with secretory granule ISO
Inferred from Sequence Orthology
more info
 
vacuole ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cathepsin L1
Names
cathepsin L1
Cat L
furless
major excreted protein
nackt
p39 cysteine proteinase
NP_034114.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009984.3NP_034114.1  cathepsin L1 preproprotein

    See identical proteins and their annotated locations for NP_034114.1

    Status: PROVISIONAL

    Source sequence(s)
    AK049466
    Consensus CDS
    CCDS26600.1
    UniProtKB/Swiss-Prot
    P06797
    UniProtKB/TrEMBL
    Q543M3
    Related
    ENSMUSP00000021933, ENSMUST00000021933
    Conserved Domains (2) summary
    smart00848
    Location:2987
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    cd02248
    Location:115331
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    64363214..64370883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517081.1XP_006517144.1  

    See identical proteins and their annotated locations for XP_006517144.1

    UniProtKB/Swiss-Prot
    P06797
    UniProtKB/TrEMBL
    Q543M3
    Conserved Domains (2) summary
    smart00848
    Location:2987
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    cd02248
    Location:115331
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
  2. XM_006517080.1XP_006517143.1  

    See identical proteins and their annotated locations for XP_006517143.1

    UniProtKB/Swiss-Prot
    P06797
    UniProtKB/TrEMBL
    Q543M3
    Conserved Domains (2) summary
    smart00848
    Location:2987
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    cd02248
    Location:115331
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    66025830..66032878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)