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    Eda ectodysplasin-A [ Mus musculus (house mouse) ]

    Gene ID: 13607, updated on 23-Aug-2016
    Official Symbol
    Edaprovided by MGI
    Official Full Name
    ectodysplasin-Aprovided by MGI
    Primary source
    MGI:MGI:1195272
    See related
    Ensembl:ENSMUSG00000059327 Vega:OTTMUSG00000018058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ta; Ed1; HED; EDA1; XLHED; tabby; Eda-A1; Eda-A2; Tnlg7c
    Orthologs
    Location:
    X C3; X 43.59 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (99975606..100400760)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (97170945..97596099)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene proliferating cell nuclear antigen pseudogene 1 Neighboring gene transmembrane protein 28 Neighboring gene zinc finger, FYVE domain containing 19 pseudogene Neighboring gene serologically defined colon cancer antigen 3 pseudogene Neighboring gene microRNA 676 Neighboring gene acyl-CoA wax alcohol acyltransferase 2 Neighboring gene OTU domain containing 6A Neighboring gene immunoglobulin (CD79A) binding protein 1

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (14)  1 citation
    • Chemically and radiation induced (2) 
    • Radiation induced (5) 
    • Chemically induced (ENU) (2)  1 citation
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle placode formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    salivary gland cavitation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trachea gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    ectodysplasin-A
    Names
    EDA protein homolog
    tumor necrosis factor ligand 7c

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177937.1NP_001171408.1  ectodysplasin-A isoform 2

      See identical proteins and their annotated locations for NP_001171408.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame small segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks two internal aa, as compared to isoform 1.
      Source sequence(s)
      AF016627, AJ243657, CJ207760, DQ168876
      UniProtKB/Swiss-Prot
      O54693
      UniProtKB/TrEMBL
      A0A0U5J8Q0, Q3UV69
      Conserved Domains (1) summary
      cd00184
      Location:249381
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    2. NM_001177938.1NP_001171409.1  ectodysplasin-A isoform 3

      See identical proteins and their annotated locations for NP_001171409.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame small segment in the CDS, as compared to variant 1. The resulting isoform (3) lacks three internal aa, as compared to isoform 1.
      Source sequence(s)
      CJ207760, DQ168877
      UniProtKB/TrEMBL
      Q1L2E0
      Conserved Domains (1) summary
      cd00184
      Location:249380
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    3. NM_001177939.1NP_001171410.1  ectodysplasin-A isoform 4

      See identical proteins and their annotated locations for NP_001171410.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two in-frame small segments in the CDS, as compared to variant 1. The resulting isoform (4) lacks five internal aa, as compared to isoform 1.
      Source sequence(s)
      AF016627, AJ243658, CJ207760, DQ168876
      Consensus CDS
      CCDS53143.1
      UniProtKB/Swiss-Prot
      O54693
      UniProtKB/TrEMBL
      Q3UV69
      Related
      ENSMUSP00000109408, OTTMUSP00000019658, ENSMUST00000113778, OTTMUST00000043780
      Conserved Domains (1) summary
      cd00184
      Location:249378
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    4. NM_001177940.1NP_001171411.1  ectodysplasin-A isoform 5

      See identical proteins and their annotated locations for NP_001171411.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (5) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      CJ207760, DQ168878
      Consensus CDS
      CCDS53144.1
      UniProtKB/TrEMBL
      Q1L2D9
      Related
      ENSMUSP00000071397, ENSMUST00000071453
      Conserved Domains (1) summary
      cd00184
      Location:241375
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    5. NM_001177941.1NP_001171412.1  ectodysplasin-A isoform 6

      See identical proteins and their annotated locations for NP_001171412.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an in-frame exon and two in-frame small segments in the CDS, as compared to variant 1. The resulting isoform (6) is shorter but has the same N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      CJ207760, DQ168879
      Consensus CDS
      CCDS53145.1
      UniProtKB/TrEMBL
      Q1L2D8
      Related
      ENSMUSP00000109411, OTTMUSP00000019659, ENSMUST00000113781, OTTMUST00000043781
      Conserved Domains (1) summary
      cd00184
      Location:241370
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    6. NM_001177942.1NP_001171413.1  ectodysplasin-A isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an in-frame segment in the CDS, as compared to variant 1. The resulting isoform (7) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AF004435, CJ207760, DQ168876
      Consensus CDS
      CCDS53141.1
      UniProtKB/Swiss-Prot
      O54693
      UniProtKB/TrEMBL
      Q3UV69
      Related
      ENSMUSP00000109410, OTTMUSP00000019657, ENSMUST00000113780, OTTMUST00000043779
      Conserved Domains (1) summary
      pfam00229
      Location:286371
      TNF; TNF(tumor Necrosis Factor) family
    7. NM_001177943.1NP_001171414.1  ectodysplasin-A isoform 8

      See identical proteins and their annotated locations for NP_001171414.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks a small segment but has an additional exon in the CDS, as compared to variant 1. The resulting isoform (8) is shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      CJ207760, DQ168880
      Consensus CDS
      CCDS53142.1
      UniProtKB/TrEMBL
      Q1L2D6
      Related
      ENSMUSP00000109406, OTTMUSP00000019584, ENSMUST00000113776, OTTMUST00000043584
      Conserved Domains (1) summary
      cl00147
      Location:249309
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    8. NM_001177944.1NP_001171415.1  ectodysplasin-A isoform 8

      See identical proteins and their annotated locations for NP_001171415.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks a small segment but has an additional exon in the CDS, as compared to variant 1. The resulting isoform (8) is shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      CJ207760, DQ168881
      Consensus CDS
      CCDS53142.1
      UniProtKB/TrEMBL
      Q1L2D6
      Related
      ENSMUSP00000109405, OTTMUSP00000019656, ENSMUST00000113775, OTTMUST00000043778
      Conserved Domains (1) summary
      cl00147
      Location:249309
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    9. NM_010099.2NP_034229.1  ectodysplasin-A isoform 1

      See identical proteins and their annotated locations for NP_034229.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL671299, AL671979, AL773561
      Consensus CDS
      CCDS30299.1
      UniProtKB/Swiss-Prot
      O54693
      UniProtKB/TrEMBL
      Q3UV69
      Related
      ENSMUSP00000109409, OTTMUSP00000019583, ENSMUST00000113779, OTTMUST00000043583
      Conserved Domains (1) summary
      cd00184
      Location:249383
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      99975606..100400760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)