Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    NQO2 NAD(P)H dehydrogenase, quinone 2 [ Homo sapiens (human) ]

    Gene ID: 4835, updated on 12-Feb-2016
    Official Symbol
    NQO2provided by HGNC
    Official Full Name
    NAD(P)H dehydrogenase, quinone 2provided by HGNC
    Primary source
    HGNC:HGNC:7856
    See related
    Ensembl:ENSG00000124588; HPRD:01190; MIM:160998; Vega:OTTHUMG00000014130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    QR2; DHQV; DIA6; NMOR2
    Summary
    This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
    Orthologs
    See NQO2 in Epigenomics, MapViewer
    Location:
    6p25.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (2988640..3019876)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (3000067..3019997)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374887 Neighboring gene serpin peptidase inhibitor, clade B (ovalbumin), member 6 Neighboring gene uncharacterized LOC105374888 Neighboring gene long intergenic non-protein coding RNA 1011 Neighboring gene HIV-1 Tat specific factor 1 pseudogene 2 Neighboring gene uncharacterized LOC101927759

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ39868

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NADPH dehydrogenase (quinone) activity TAS
    Traceable Author Statement
    more info
    PubMed 
    electron carrier activity TAS
    Traceable Author Statement
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    ribosyldihydronicotinamide dehydrogenase [quinone]
    Names
    NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2
    NRH:quinone oxidoreductase 2
    quinone reductase 2
    ribosyldihydronicotinamide dehydrogenase
    NP_000895.2
    NP_001277150.1
    NP_001277151.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034013.1 RefSeqGene

      Range
      5001..25061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000904.4NP_000895.2  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      See identical proteins and their annotated locations for NP_000895.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks three exons in the 5' UTR compared to variant 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AK056981, AK311746, AL133351, BC006096, CD014013
      Consensus CDS
      CCDS4481.1
      UniProtKB/TrEMBL
      B3KPX6
      UniProtKB/Swiss-Prot
      P16083
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold
    2. NM_001290221.1NP_001277150.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      See identical proteins and their annotated locations for NP_001277150.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 3, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AK056981, AK311746, AL133351, CD014013, J02888
      Consensus CDS
      CCDS4481.1
      UniProtKB/TrEMBL
      B3KPX6
      UniProtKB/Swiss-Prot
      P16083
      Related
      ENSP00000337773, OTTHUMP00000015949, ENST00000338130, OTTHUMT00000039651
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold
    3. NM_001290222.1NP_001277151.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 2

      See identical proteins and their annotated locations for NP_001277151.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three exons in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AL133351, BI670476, CD014013
      Consensus CDS
      CCDS75388.1
      UniProtKB/TrEMBL
      Q5TD07
      Conserved Domains (1) summary
      pfam02525
      Location:5174
      Flavodoxin_2; Flavodoxin-like fold
    4. NM_001318940.1NP_001305869.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AK056981, AL133351, BI333292, CD014013
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

      Range
      2988640..3019876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514644.1XP_011512946.1  

      UniProtKB/Swiss-Prot
      P16083
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold
    2. XM_011514643.1XP_011512945.1  

      UniProtKB/Swiss-Prot
      P16083
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold
    3. XM_011514646.1XP_011512948.1  

      See identical proteins and their annotated locations for XP_011512948.1

      UniProtKB/Swiss-Prot
      P16083
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold
    4. XM_005249150.2XP_005249207.1  

      See identical proteins and their annotated locations for XP_005249207.1

      UniProtKB/Swiss-Prot
      P16083
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold
    5. XM_006715100.1XP_006715163.1  

      See identical proteins and their annotated locations for XP_006715163.1

      UniProtKB/Swiss-Prot
      P16083
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold
    6. XM_005249149.2XP_005249206.1  

      See identical proteins and their annotated locations for XP_005249206.1

      UniProtKB/Swiss-Prot
      P16083
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold
    7. XM_005249148.2XP_005249205.1  

      See identical proteins and their annotated locations for XP_005249205.1

      UniProtKB/Swiss-Prot
      P16083
      Related
      ENSP00000369806, OTTHUMP00000015950, ENST00000380441, OTTHUMT00000039652
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold
    8. XM_011514645.1XP_011512947.1  

      See identical proteins and their annotated locations for XP_011512947.1

      UniProtKB/Swiss-Prot
      P16083
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold
    9. XM_005249151.3XP_005249208.1  

      See identical proteins and their annotated locations for XP_005249208.1

      UniProtKB/Swiss-Prot
      P16083
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold
    10. XM_011514642.1XP_011512944.1  

      Conserved Domains (1) summary
      pfam02525
      Location:5175
      Flavodoxin_2; Flavodoxin-like fold

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      3002414..3022477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)