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    Klk6 kallikrein related-peptidase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29245, updated on 15-Nov-2015
    Official Symbol
    Klk6provided by RGD
    Official Full Name
    kallikrein related-peptidase 6provided by RGD
    Primary source
    RGD:3419
    See related
    Ensembl:ENSRNOG00000031927
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prss9
    Summary
    a myelencephalon-specific protease which has trypsin-like substrate specificity; expressed in the nervous system [RGD, Feb 2006]
    Orthologs
    Location:
    1q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (99762221..99769496)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (100830974..100838254)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene kallikrein related-peptidase 8 Neighboring gene kallikrein-related peptidase 7 Neighboring gene kallikrein related-peptidase 5 Neighboring gene kallikrein-related peptidase 4

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of G-protein coupled receptor protein signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of G-protein coupled receptor protein signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    kallikrein-6
    Names
    kallikrein 6 (neurosin)
    kallikrein 6 (neurosin, zyme)
    protease serine 9 (neurosin)
    protease, serine, 9

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019175.1NP_062048.1  kallikrein-6 precursor

      See identical proteins and their annotated locations for NP_062048.1

      Status: PROVISIONAL

      Source sequence(s)
      AF016269
      UniProtKB/TrEMBL
      O54854
      Related
      ENSRNOP00000060676, ENSRNOT00000065876
      Conserved Domains (2) summary
      smart00020
      Location:28244
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:29247
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      99762221..99769496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228982.2XP_006229044.1  

      See identical proteins and their annotated locations for XP_006229044.1

      UniProtKB/TrEMBL
      O54854
      Conserved Domains (2) summary
      smart00020
      Location:28244
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:29247
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      88546437..88553549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)