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    TAAR6 trace amine associated receptor 6 [ Homo sapiens (human) ]

    Gene ID: 319100, updated on 26-Jun-2015
    Official Symbol
    TAAR6provided by HGNC
    Official Full Name
    trace amine associated receptor 6provided by HGNC
    Primary source
    HGNC:HGNC:20978
    See related
    Ensembl:ENSG00000146383; HPRD:16404; MIM:608923; Vega:OTTHUMG00000015579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TA4; TAR4; TAR6; TRAR4; taR-4; taR-6
    Summary
    This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010]
    Orthologs
    See TAAR6 in Epigenomics, MapViewer
    Location:
    6q23.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (132570322..132571359)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132891461..132892498)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene trace amine associated receptor 8 Neighboring gene trace amine associated receptor 7, pseudogene Neighboring gene trace amine associated receptor 5 Neighboring gene trace amine associated receptor 4, pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Amine ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine)...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    trace-amine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IC
    Inferred by Curator
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    trace amine-associated receptor 6
    Names
    trace amine-associated receptor 6
    trace amine receptor 4
    trace amine receptor 6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016544.1 RefSeqGene

      Range
      5001..6038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_175067.1NP_778237.1  trace amine-associated receptor 6

      See identical proteins and their annotated locations for NP_778237.1

      Status: REVIEWED

      Source sequence(s)
      AY183470
      Consensus CDS
      CCDS5155.1
      UniProtKB/Swiss-Prot
      Q96RI8
      Related
      ENSP00000275198, OTTHUMP00000017222, ENST00000275198, OTTHUMT00000042255
      Conserved Domains (2) summary
      pfam00001
      Location:57311
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam10320
      Location:43271
      7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

      Range
      132570322..132571359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      133155132..133156169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)