Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Tjp1 tight junction protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 21872, updated on 3-Jul-2016
    Official Symbol
    Tjp1provided by MGI
    Official Full Name
    tight junction protein 1provided by MGI
    Primary source
    MGI:MGI:98759
    See related
    Ensembl:ENSMUSG00000030516 Vega:OTTMUSG00000016466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZO1
    Orthologs
    Location:
    7 C; 7 35.02 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (65296165..65527808, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (72441051..72516130, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810049I09 gene Neighboring gene apolipoprotein O pseudogene Neighboring gene predicted gene, 33068 Neighboring gene cDNA sequence BC046251 Neighboring gene threonyl-tRNA synthetase-like 2 Neighboring gene predicted gene, 33234

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    blastocyst formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of endothelial intestinal barrier ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical junction complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    gap junction IEA
    Inferred from Electronic Annotation
    more info
     
    intercalated disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intercellular canaliculus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    tight junction protein ZO-1
    Names
    zona occludens protein 1
    zonula occludens protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163574.1NP_001157046.1  tight junction protein ZO-1 isoform 2

      See identical proteins and their annotated locations for NP_001157046.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon in the middle region but has an additional in-frame segment in the 3' coding region, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BC138028, BP760988, CJ098724
      Consensus CDS
      CCDS52266.1
      UniProtKB/TrEMBL
      B9EHJ3
      Related
      ENSMUSP00000032729, OTTMUSP00000050574, ENSMUST00000032729, OTTMUST00000039676
      Conserved Domains (5) summary
      PTZ00249
      Location:10771280
      PTZ00249; variable surface protein Vir28; Provisional
      pfam00791
      Location:15491653
      ZU5; ZU5 domain
      cd12026
      Location:517581
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:615794
      GuKc; Guanylate kinase homologues
      cd00992
      Location:22107
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. NM_009386.2NP_033412.2  tight junction protein ZO-1 isoform 1

      See identical proteins and their annotated locations for NP_033412.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC122222, AC131741
      Consensus CDS
      CCDS21338.1
      UniProtKB/Swiss-Prot
      P39447
      Related
      ENSMUSP00000099652, OTTMUSP00000017707, ENSMUST00000102592, OTTMUST00000039673
      Conserved Domains (5) summary
      PTZ00249
      Location:11571360
      PTZ00249; variable surface protein Vir28; Provisional
      pfam00791
      Location:16291719
      ZU5; ZU5 domain
      cd12026
      Location:517581
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:615794
      GuKc; Guanylate kinase homologues
      cd00992
      Location:22107
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      65296165..65527808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540778.3XP_006540841.1  

      Conserved Domains (5) summary
      PTZ00249
      Location:12501453
      PTZ00249; variable surface protein Vir28; Provisional
      pfam00791
      Location:17391843
      ZU5; ZU5 domain
      cd12026
      Location:610674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708887
      GuKc; Guanylate kinase homologues
      cd00992
      Location:115200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. XM_006540785.3XP_006540848.1  

      Conserved Domains (5) summary
      PTZ00249
      Location:11701373
      PTZ00249; variable surface protein Vir28; Provisional
      pfam00791
      Location:16421746
      ZU5; ZU5 domain
      cd12026
      Location:610674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708887
      GuKc; Guanylate kinase homologues
      cd00992
      Location:115200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    3. XM_006540780.3XP_006540843.1  

      Conserved Domains (5) summary
      PTZ00249
      Location:12501453
      PTZ00249; variable surface protein Vir28; Provisional
      pfam00791
      Location:17221826
      ZU5; ZU5 domain
      cd12026
      Location:610674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708887
      GuKc; Guanylate kinase homologues
      cd00992
      Location:115200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    4. XM_006540783.3XP_006540846.1  

      Conserved Domains (5) summary
      PTZ00249
      Location:11701373
      PTZ00249; variable surface protein Vir28; Provisional
      pfam00791
      Location:16591763
      ZU5; ZU5 domain
      cd12026
      Location:610674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708887
      GuKc; Guanylate kinase homologues
      cd00992
      Location:115200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    5. XM_006540784.3XP_006540847.1  

      Conserved Domains (5) summary
      PTZ00249
      Location:11571360
      PTZ00249; variable surface protein Vir28; Provisional
      pfam00791
      Location:16461750
      ZU5; ZU5 domain
      cd12026
      Location:517581
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:615794
      GuKc; Guanylate kinase homologues
      cd00992
      Location:22107
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    6. XM_006540779.3XP_006540842.1  

      Conserved Domains (5) summary
      PTZ00249
      Location:12501453
      PTZ00249; variable surface protein Vir28; Provisional
      pfam00791
      Location:17391832
      ZU5; ZU5 domain
      cd12026
      Location:610674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708887
      GuKc; Guanylate kinase homologues
      cd00992
      Location:115200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    7. XM_006540786.3XP_006540849.1  

      Conserved Domains (5) summary
      PTZ00249
      Location:11701373
      PTZ00249; variable surface protein Vir28; Provisional
      pfam00791
      Location:16421732
      ZU5; ZU5 domain
      cd12026
      Location:610674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708887
      GuKc; Guanylate kinase homologues
      cd00992
      Location:115200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    8. XM_006540782.3XP_006540845.1  

      Conserved Domains (5) summary
      PTZ00249
      Location:12501453
      PTZ00249; variable surface protein Vir28; Provisional
      pfam00791
      Location:17221812
      ZU5; ZU5 domain
      cd12026
      Location:610674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708887
      GuKc; Guanylate kinase homologues
      cd00992
      Location:115200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    9. XM_011250843.2XP_011249145.1  

      Conserved Domains (5) summary
      PTZ00249
      Location:12501453
      PTZ00249; variable surface protein Vir28; Provisional
      pfam00791
      Location:17221815
      ZU5; ZU5 domain
      cd12026
      Location:610674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708887
      GuKc; Guanylate kinase homologues
      cd00992
      Location:115200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    10. XM_006540781.3XP_006540844.1  

      Conserved Domains (5) summary
      PTZ00249
      Location:12501453
      PTZ00249; variable surface protein Vir28; Provisional
      pfam00791
      Location:17391829
      ZU5; ZU5 domain
      cd12026
      Location:610674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708887
      GuKc; Guanylate kinase homologues
      cd00992
      Location:115200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...