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Gas6 growth arrest specific 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58935, updated on 14-Sep-2014
Official Symbol
Gas6provided by RGD
Official Full Name
growth arrest specific 6provided by RGD
Primary source
RGD:61913
See related
Ensembl:ENSRNOG00000018233
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
provides protection of neurons against serum deprivation-induced apoptosis [RGD, Feb 2006]
See Gas6 in MapViewer
Location:
16q12.5
Exon count:
15
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81213364..81243757, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (80701559..80732410, complement)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene transmembrane protein 255B Neighboring gene uncharacterized LOC103693998 Neighboring gene similar to RIKEN cDNA 1700029H14

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
binding, bridging ISO
Inferred from Sequence Orthology
more info
 
binding, bridging ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
growth factor activity TAS
Traceable Author Statement
more info
PubMed 
phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor agonist activity IEA
Inferred from Electronic Annotation
more info
 
receptor agonist activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
receptor tyrosine kinase binding TAS
Traceable Author Statement
more info
PubMed 
voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
B cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
B cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
 
apoptotic cell clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
blood coagulation ISO
Inferred from Sequence Orthology
more info
 
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
 
cellular response to interferon-alpha ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to starvation IEA
Inferred from Electronic Annotation
more info
 
cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
cellular response to vitamin K ISO
Inferred from Sequence Orthology
more info
 
cellular response to vitamin K ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
enzyme linked receptor protein signaling pathway IEA
Inferred from Electronic Annotation
more info
 
enzyme linked receptor protein signaling pathway ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix assembly IEP
Inferred from Expression Pattern
more info
PubMed 
fusion of virus membrane with host plasma membrane ISO
Inferred from Sequence Orthology
more info
 
fusion of virus membrane with host plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
hematopoietic stem cell migration to bone marrow ISO
Inferred from Sequence Orthology
more info
 
hematopoietic stem cell migration to bone marrow ISS
Inferred from Sequence or Structural Similarity
more info
 
macrophage cytokine production IEA
Inferred from Electronic Annotation
more info
 
macrophage cytokine production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of biomineral tissue development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of biomineral tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of dendritic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dendritic cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of fibroblast apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibroblast apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interferon-gamma production ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-1 secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-1 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of oligodendrocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oligodendrocyte apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein import into nucleus, translocation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein import into nucleus, translocation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of renal albumin absorption IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
phagocytosis ISO
Inferred from Sequence Orthology
more info
 
phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of TOR signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of dendritic cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glomerular filtration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of natural killer cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of natural killer cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein targeting to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein targeting to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor-mediated virion attachment to host cell ISO
Inferred from Sequence Orthology
more info
 
receptor-mediated virion attachment to host cell ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
tissue regeneration TAS
Traceable Author Statement
more info
PubMed 
tissue remodeling TAS
Traceable Author Statement
more info
PubMed 
viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
viral entry into host cell ISS
Inferred from Sequence or Structural Similarity
more info
 
viral genome replication ISO
Inferred from Sequence Orthology
more info
 
viral genome replication ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
intracellular ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
growth arrest-specific protein 6
Names
growth arrest-specific protein 6
GPF
GAS-6
growth-potentiating factor
AXL receptor tyrosine kinase ligand

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_057100.2NP_476441.2  growth arrest-specific protein 6 precursor

    See proteins identical to NP_476441.2

    Status: PROVISIONAL

    Source sequence(s)
    BC070881
    UniProtKB/TrEMBL
    Q6IRL1
    Related
    ENSRNOP00000024677, ENSRNOT00000024677
    Conserved Domains (4) summary
    smart00069
    Location:2690
    Blast Score: 254
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:194234
    Blast Score: 114
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:295447
    Blast Score: 290
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam14670
    Location:157192
    Blast Score: 146
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 

    Range
    81213364..81243757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000084.1 

    Range
    73852900..73883275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)