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    CCL7 C-C motif chemokine ligand 7 [ Homo sapiens (human) ]

    Gene ID: 6354, updated on 22-Sep-2016
    Official Symbol
    CCL7provided by HGNC
    Official Full Name
    C-C motif chemokine ligand 7provided by HGNC
    Primary source
    HGNC:HGNC:10634
    See related
    Ensembl:ENSG00000108688 HPRD:01150; MIM:158106; Vega:OTTHUMG00000132889
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7
    Summary
    This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    17q11.2-q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (34270216..34272242)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (32597235..32599261)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927239 Neighboring gene C-C motif chemokine ligand 2 Neighboring gene C-C motif chemokine ligand 11 Neighboring gene C-C motif chemokine ligand 8

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    NHGRI GWA Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Chemokines such as MCP-3 and MCP-2 that can compete with high affinity for MIP-1beta binding to CCR5 can also compete for monomeric HIV-1 gp120 binding to CCR5, although with variable potencies PubMed
    Tat tat HIV-1 and the viral protein Tat modulate the expression of chemokine (C-C motif) ligand 7 (CCL7; MCP-3) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat HIV-1 Tat upregulates expression of MCP-3 in immature dendritic cells, suggesting Tat reprograms host dendritic cell gene expression to facilitate expansion of HIV-1 infection PubMed
    tat HIV-1 Tat is a competitive inhibitor of MCP-3 binding to CCR3 PubMed

    Go to the HIV-1, Human Interaction Database

    • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
      Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC138463, MGC138465

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    CCR1 chemokine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    CCR2 chemokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular calcium ion homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interferon-gamma IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to interleukin-1 IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to tumor necrosis factor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eosinophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    monocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    monocyte chemotaxis IC
    Inferred by Curator
    more info
    PubMed 
    neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of natural killer cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    C-C motif chemokine 7
    Names
    chemokine (C-C motif) ligand 7
    monocyte chemoattractant protein 3
    monocyte chemotactic protein 3
    small inducible cytokine A7 (monocyte chemotactic protein 3)
    small-inducible cytokine A7

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006273.3NP_006264.2  C-C motif chemokine 7 precursor

      See identical proteins and their annotated locations for NP_006264.2

      Status: REVIEWED

      Source sequence(s)
      AC005549, CD523198, X71087
      Consensus CDS
      CCDS11278.1
      UniProtKB/Swiss-Prot
      P80098
      Related
      ENSP00000367832, OTTHUMP00000163801, ENST00000378569, OTTHUMT00000256386
      Conserved Domains (1) summary
      smart00199
      Location:3190
      SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      34270216..34272242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      32661096..32663122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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