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    Aldh3a1 aldehyde dehydrogenase 3 family, member A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25375, updated on 22-Nov-2015
    Official Symbol
    Aldh3a1provided by RGD
    Official Full Name
    aldehyde dehydrogenase 3 family, member A1provided by RGD
    Primary source
    RGD:2088
    See related
    Ensembl:ENSRNOG00000002331
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AHDC; Aldh; Ahd-c; Aldh3
    Summary
    aldehyde dehydrogenase that is expressed during hepatocarcinogenesis [RGD, Feb 2006]
    Orthologs
    See Aldh3a1 in MapViewer
    Location:
    10q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (47490168..47499855)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (47265007..47274692)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 13B Neighboring gene ubiquitin specific peptidase 22 Neighboring gene similar to Related RAS viral (r-ras) oncogene homolog 2 Neighboring gene aldehyde dehydrogenase 3 family, member A2

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    3-chloroallyl aldehyde dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    3-chloroallyl aldehyde dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    alcohol dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    alcohol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    aldehyde dehydrogenase (NAD) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    aldehyde dehydrogenase (NAD) activity ISO
    Inferred from Sequence Orthology
    more info
     
    aldehyde dehydrogenase (NAD) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    aldehyde dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
     
    benzaldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    benzaldehyde dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular aldehyde metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular aldehyde metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to cAMP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    aldehyde dehydrogenase, dimeric NADP-preferring
    Names
    Aldehyde dehydrogenase (Ahd-c)
    HTC-ALDH
    aldehyde dehydrogenase 3A1
    aldehyde dehydrogenase class 3
    aldehyde dehydrogenase family 3 member A1
    aldehyde dehydrogenase family 3 subfamily A1
    aldehyde dehydrogenase family 3, member A1
    tumor-associated aldehyde dehydrogenase tumor ALDH
    NP_114178.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031972.1NP_114178.1  aldehyde dehydrogenase, dimeric NADP-preferring

      See identical proteins and their annotated locations for NP_114178.1

      Status: PROVISIONAL

      Source sequence(s)
      J03637
      UniProtKB/Swiss-Prot
      P11883
      Related
      ENSRNOP00000003182, ENSRNOT00000003182
      Conserved Domains (1) summary
      cd07132
      Location:5447
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      47490168..47499855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      45146398..45156083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)