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    Ptpn18 protein tyrosine phosphatase, non-receptor type 18 [ Mus musculus (house mouse) ]

    Gene ID: 19253, updated on 16-Jul-2016
    Official Symbol
    Ptpn18provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 18provided by MGI
    Primary source
    MGI:MGI:108410
    See related
    Ensembl:ENSMUSG00000026126 Vega:OTTMUSG00000049465
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FLP1; HSCF; Ptpk1; PTP-K1; PTP-HSCF
    Orthologs
    Location:
    1 B; 1 13.25 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (34459746..34473784)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (34516591..34530629)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 115 Neighboring gene IMP4, U3 small nucleolar ribonucleoprotein Neighboring gene predicted gene, 32504 Neighboring gene RIKEN cDNA 4930568A12 gene Neighboring gene predicted gene, 32566 Neighboring gene protease, serine 39

    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ???? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation...

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    tyrosine-protein phosphatase non-receptor type 18
    Names
    FLP-1
    fetal liver phosphatase 1
    NP_035336.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011206.2NP_035336.2  tyrosine-protein phosphatase non-receptor type 18

      See identical proteins and their annotated locations for NP_035336.2

      Status: VALIDATED

      Source sequence(s)
      AK144353, CD740968, CJ166432
      Consensus CDS
      CCDS14867.1
      UniProtKB/Swiss-Prot
      Q61152
      Related
      ENSMUSP00000027302, OTTMUSP00000068237, ENSMUST00000027302, OTTMUST00000126097
      Conserved Domains (2) summary
      cd00047
      Location:59290
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:56290
      Y_phosphatase; Protein-tyrosine phosphatase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      34459746..34473784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495800.3XP_006495863.1  

      Conserved Domains (2) summary
      smart00194
      Location:22266
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:35266
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. XM_017319374.1XP_017174863.1