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    LHX2 LIM homeobox 2 [ Homo sapiens (human) ]

    Gene ID: 9355, updated on 13-Aug-2016
    Official Symbol
    LHX2provided by HGNC
    Official Full Name
    LIM homeobox 2provided by HGNC
    Primary source
    HGNC:HGNC:6594
    See related
    Ensembl:ENSG00000106689 HPRD:04786; MIM:603759; Vega:OTTHUMG00000020647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LH2; hLhx2
    Summary
    This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    9q33.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (124011610..124033163)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (126773889..126795572)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376267 Neighboring gene uncharacterized LOC100505588 Neighboring gene uncharacterized LOC105376268 Neighboring gene uncharacterized LOC107987037 Neighboring gene myeloproliferative disease associated tumor antigen 5 Neighboring gene NIMA related kinase 6

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
    NHGRI GWA Catalog
    Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.
    NHGRI GWA Catalog
    • Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
      Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC138390

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, RNA polymerase II transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    hair follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    maintenance of epithelial cell apical/basal polarity IEA
    Inferred from Electronic Annotation
    more info
     
    mesoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    olfactory bulb development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    retina development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    telencephalon regionalization IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    LIM/homeobox protein Lhx2
    Names
    LIM HOX gene 2
    LIM homeobox protein 2
    homeobox protein LH-2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004789.3NP_004780.3  LIM/homeobox protein Lhx2

      See identical proteins and their annotated locations for NP_004780.3

      Status: REVIEWED

      Source sequence(s)
      AK027597
      Consensus CDS
      CCDS6853.1
      UniProtKB/Swiss-Prot
      P50458
      UniProtKB/TrEMBL
      B3KNJ5
      Related
      ENSP00000362717, OTTHUMP00000022092, ENST00000373615, OTTHUMT00000054010
      Conserved Domains (4) summary
      cd09377
      Location:111169
      LIM2_Lhx2_Lhx9; The second LIM domain of Lhx2 and Lhx9 family
      cd09469
      Location:43106
      LIM1_Lhx2; The first LIM domain of Lhx2
      COG5576
      Location:247378
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:270322
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      124011610..124033163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717323.2XP_006717386.1  

      See identical proteins and their annotated locations for XP_006717386.1

      Conserved Domains (3) summary
      cd09377
      Location:111169
      LIM2_Lhx2_Lhx9; The second LIM domain of Lhx2 and Lhx9 family
      cd09469
      Location:43106
      LIM1_Lhx2; The first LIM domain of Lhx2
      cd00086
      Location:267311
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      126922665..126944218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)