Display Settings:

Format

Send to:

Choose Destination

Ptgs1 prostaglandin-endoperoxide synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 19224, updated on 5-Apr-2015
Official Symbol
Ptgs1provided by MGI
Official Full Name
prostaglandin-endoperoxide synthase 1provided by MGI
Primary source
MGI:MGI:97797
See related
Ensembl:ENSMUSG00000047250; Vega:OTTMUSG00000012142
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
COX1; Cox-1; Cox-3; PHS 1; Pghs1; PGHS-1
Summary
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]
Orthologs
See Ptgs1 in MapViewer
Location:
2 B; 2 24.19 cM
Exon count:
19
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (36216743..36252275)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (36085946..36107789)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene Neighboring gene mitochondrial ribosome recycling factor Neighboring gene predicted gene 13429 Neighboring gene olfactory receptor 334, pseudogene 1 Neighboring gene olfactory receptor 335, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
lipid binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
prostaglandin-endoperoxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cyclooxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
keratinocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
learning ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
maintenance of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
memory ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
prostaglandin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
prostaglandin G/H synthase 1
Names
prostaglandin G/H synthase 1
PGH synthase 1
cyclooxygenase-1
prostaglandin H2 synthase 1
NP_032995.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008969.4NP_032995.1  prostaglandin G/H synthase 1 precursor

    See identical proteins and their annotated locations for NP_032995.1

    Status: REVIEWED

    Source sequence(s)
    AK159907, AW493573
    Consensus CDS
    CCDS15970.1
    UniProtKB/Swiss-Prot
    P22437
    UniProtKB/TrEMBL
    Q543T1
    Related
    ENSMUSP00000059977, OTTMUSP00000013094, ENSMUST00000062069, OTTMUST00000028971
    Conserved Domains (3) summary
    cd09816
    Location:92578
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3572
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:148584
    An_peroxidase; Animal haem peroxidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    36216743..36252275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239036.1XP_011237338.1  

    See identical proteins and their annotated locations for XP_011237338.1

    Conserved Domains (3) summary
    cd09816
    Location:92578
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3572
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:148584
    An_peroxidase; Animal haem peroxidase
  2. XM_006497790.2XP_006497853.1  

    See identical proteins and their annotated locations for XP_006497853.1

    UniProtKB/Swiss-Prot
    P22437
    UniProtKB/TrEMBL
    Q543T1
    Conserved Domains (3) summary
    cd09816
    Location:92578
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3572
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:148584
    An_peroxidase; Animal haem peroxidase
  3. XM_006497791.2XP_006497854.1  

    See identical proteins and their annotated locations for XP_006497854.1

    UniProtKB/Swiss-Prot
    P22437
    UniProtKB/TrEMBL
    Q543T1
    Conserved Domains (3) summary
    cd09816
    Location:92578
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3572
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:148584
    An_peroxidase; Animal haem peroxidase
  4. XM_006497793.2XP_006497856.1  

    See identical proteins and their annotated locations for XP_006497856.1

    UniProtKB/Swiss-Prot
    P22437
    UniProtKB/TrEMBL
    Q543T1
    Conserved Domains (3) summary
    cd09816
    Location:92578
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3572
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:148584
    An_peroxidase; Animal haem peroxidase
  5. XM_006497794.2XP_006497857.1  

    Conserved Domains (3) summary
    cd09816
    Location:74560
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:1754
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:130566
    An_peroxidase; Animal haem peroxidase
  6. XM_006497795.1XP_006497858.1  

    Conserved Domains (2) summary
    pfam03098
    Location:2298
    An_peroxidase; Animal haem peroxidase
    cl14561
    Location:1292
    An_peroxidase_like; Animal heme peroxidases and related proteins

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    35934252..35956095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)