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    ANXA1 annexin A1 [ Homo sapiens (human) ]

    Gene ID: 301, updated on 26-Jul-2015
    Official Symbol
    ANXA1provided by HGNC
    Official Full Name
    annexin A1provided by HGNC
    Primary source
    HGNC:HGNC:533
    See related
    Ensembl:ENSG00000135046; HPRD:01060; MIM:151690; Vega:OTTHUMG00000020016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANX1; LPC1
    Summary
    This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
    Orthologs
    See ANXA1 in Epigenomics, MapViewer
    Location:
    9q21.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (73151731..73170393)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (75766721..75785309)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 1, subfamily D, polypeptide 1, pseudogene Neighboring gene uncharacterized LOC105376081 Neighboring gene uncharacterized LOC105376082 Neighboring gene uncharacterized LOC101927281

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of annexin A4 and V in umbilical cord blood mononuclear cells and T-cell lines but downregulates the expression of annexin A1 in umbilical cord blood mononuclear cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystem (from REACTOME)
      Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystemThe formyl peptide receptor (FPR) was defined pharmacologically in 1976 as a high affinity binding site on the surface of neutrophils for the peptide N-formyl-methionine-leucine-phenylalanine (fMLF)....
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
      Prostaglandin Synthesis and Regulation, organism-specific biosystem
      Prostaglandin Synthesis and Regulation
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ18726

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    annealing helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    double-stranded DNA-dependent ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase A2 inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    structural molecule activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA rewinding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA strand renaturation IEA
    Inferred from Electronic Annotation
    more info
     
    alpha-beta T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    arachidonic acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucocorticoid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    endocrine pancreas development IEA
    Inferred from Electronic Annotation
    more info
     
    estrous cycle IEA
    Inferred from Electronic Annotation
    more info
     
    gliogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    movement of cell or subcellular component TAS
    Traceable Author Statement
    more info
    PubMed 
    myoblast migration involved in skeletal muscle regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of interleukin-8 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptide cross-linking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neutrophil apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of prostaglandin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vesicle fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prolactin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    prostate gland development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    response to X-ray IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cilium IEA
    Inferred from Electronic Annotation
    more info
     
    cornified envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mast cell granule IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    annexin A1
    Names
    annexin I (lipocortin I)
    annexin-1
    calpactin II
    calpactin-2
    chromobindin-9
    phospholipase A2 inhibitory protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000700.2NP_000691.1  annexin A1

      See identical proteins and their annotated locations for NP_000691.1

      Status: REVIEWED

      Source sequence(s)
      AA039737, AL359997, CX870105, X05908
      Consensus CDS
      CCDS6645.1
      UniProtKB/Swiss-Prot
      P04083
      UniProtKB/TrEMBL
      Q5TZZ9
      Related
      ENSP00000257497, OTTHUMP00000021474, ENST00000257497, OTTHUMT00000052664
      Conserved Domains (1) summary
      pfam00191
      Location:118183
      Annexin; Annexin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

      Range
      73151731..73170393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518608.1XP_011516910.1  

      See identical proteins and their annotated locations for XP_011516910.1

      Conserved Domains (1) summary
      pfam00191
      Location:129194
      Annexin; Annexin
    2. XM_011518609.1XP_011516911.1  

      See identical proteins and their annotated locations for XP_011516911.1

      UniProtKB/Swiss-Prot
      P04083
      UniProtKB/TrEMBL
      Q5TZZ9
      Conserved Domains (1) summary
      pfam00191
      Location:118183
      Annexin; Annexin

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      75913496..75932176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)