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IRE1 Ire1p [ Saccharomyces cerevisiae S288c ]

Gene ID: 856478, updated on 6-Jul-2014
Gene symbol
IRE1
Gene description
Ire1p
Primary source
SGD:S000001121
Locus tag
YHR079C
Gene type
protein coding
RNA name
Ire1p
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ERN1
See IRE1 in MapViewer
Location:
chromosome: VIII
Exon count :
1
Sequence:
Chromosome: VIII; NC_001140.6 (258244..261591, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Nmd2p Neighboring gene hypothetical protein Neighboring gene Sae3p Neighboring gene hypothetical protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
endoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
ribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
fungal-type cell wall organization IGI
Inferred from Genetic Interaction
more info
PubMed 
fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
inositol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein trans-autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Names
Ire1p
NP_011946.1
  • Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 

    Range
    258244..261591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179209.1NP_011946.1  Ire1p [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_011946.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P32361
    Conserved Domains (4) summary
    cd00180
    Location:680978
    Blast Score: 398
    PKc; Catalytic domain of Protein Kinases
    cd09769
    Location:120407
    Blast Score: 737
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:9841113
    Blast Score: 550
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    smart00220
    Location:678980
    Blast Score: 456
    S_TKc; Serine/Threonine protein kinases, catalytic domain

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