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    IL2RG interleukin 2 receptor, gamma [ Homo sapiens (human) ]

    Gene ID: 3561, updated on 5-Jul-2015
    Official Symbol
    IL2RGprovided by HGNC
    Official Full Name
    interleukin 2 receptor, gammaprovided by HGNC
    Primary source
    HGNC:HGNC:6010
    See related
    Ensembl:ENSG00000147168; HPRD:02391; MIM:308380; Vega:OTTHUMG00000021787
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1
    Summary
    The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
    Orthologs
    See IL2RG in Epigenomics, MapViewer
    Location:
    Xq13.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (71107404..71111631, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70327254..70331481, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene forkhead box O4 Neighboring gene chromosome X open reading frame 65 Neighboring gene mediator complex subunit 12 Neighboring gene uncharacterized LOC105373246 Neighboring gene neuroligin 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The inhibition of IL-2R expression and proliferation induced by the interaction of CD4 with HIV-1 envelope glycoprotein gp120 is correlated with the inhibition of expression and activation of Janus kinase JAK3 PubMed
    env HIV-1 gp120 exerts a dose-dependent reduction of IL-2 mRNA expression, IL-2 production, and surface IL-2 receptor expression in CD4+ lymphocytes PubMed
    Vpu vpu HIV-1 Vpu downregulates the cell surface expression of interleukin 2 receptor, gamma (IL2RG, CD132) PubMed

    Go to the HIV-1, Human Interaction Database

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    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
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    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
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    • Downstream signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      Downstream signaling in naive CD8+ T cells, organism-specific biosystem
      Downstream signaling in naive CD8+ T cells
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
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    • G beta:gamma signalling through PI3Kgamma, organism-specific biosystem (from REACTOME)
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    • G-protein beta:gamma signalling, organism-specific biosystem (from REACTOME)
      G-protein beta:gamma signalling, organism-specific biosystemThe classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known tha...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
      GPVI-mediated activation cascade, organism-specific biosystemThe GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate plat...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • IL-2 Signaling pathway, organism-specific biosystem (from WikiPathways)
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    • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
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    • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common ga...
    • IL-9 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-9 Signaling Pathway, organism-specific biosystemInterleukin-9 belongs to a family of cytokines, which includes IL-2, IL-4, IL-7, IL-15 and IL-21. It signals through a receptor complex consisting of an IL-9 receptor (IL9R) and a common gamma chain ...
    • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL12-mediated signaling events, organism-specific biosystem
      IL12-mediated signaling events
    • IL2 signaling events mediated by PI3K, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by PI3K, organism-specific biosystem
      IL2 signaling events mediated by PI3K
    • IL2 signaling events mediated by STAT5, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by STAT5, organism-specific biosystem
      IL2 signaling events mediated by STAT5
    • IL2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL2-mediated signaling events, organism-specific biosystem
      IL2-mediated signaling events
    • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL4-mediated signaling events, organism-specific biosystem
      IL4-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
      Inflammatory Response Pathway, organism-specific biosystem
      Inflammatory Response Pathway
    • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
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    • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
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    • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
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    • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
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    • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
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    • Interleukin-7 signaling, organism-specific biosystem (from REACTOME)
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    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
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    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
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      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Primary immunodeficiency, organism-specific biosystem (from KEGG)
      Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Primary immunodeficiency, conserved biosystem (from KEGG)
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    • Signal Transduction, organism-specific biosystem (from REACTOME)
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    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
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    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    interleukin-2 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to interleukin-2 receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    contributes_to interleukin-4 receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-7 binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to interleukin-7 receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-2-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-4-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-7-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    cytokine receptor common subunit gamma
    Names
    CD132 antigen
    IL-2 receptor subunit gamma
    IL-2R subunit gamma
    common cytokine receptor gamma chain
    gammaC

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009088.1 RefSeqGene

      Range
      4923..9150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_150

    mRNA and Protein(s)

    1. NM_000206.2NP_000197.1  cytokine receptor common subunit gamma precursor

      See identical proteins and their annotated locations for NP_000197.1

      Status: REVIEWED

      Source sequence(s)
      BC014972, DC345219
      Consensus CDS
      CCDS14406.1
      UniProtKB/Swiss-Prot
      P31785
      Related
      ENSP00000363318, OTTHUMP00000023489, ENST00000374202, OTTHUMT00000057102
      Conserved Domains (2) summary
      cd00063
      Location:154246
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:59151
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

      Range
      71107404..71111631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      70219589..70223820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)