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    FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens (human) ]

    Gene ID: 2263, updated on 30-Aug-2015
    Official Symbol
    FGFR2provided by HGNC
    Official Full Name
    fibroblast growth factor receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:3689
    See related
    Ensembl:ENSG00000066468; HPRD:01492; MIM:176943; Vega:OTTHUMG00000019175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM
    Summary
    The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
    Orthologs
    See FGFR2 in Epigenomics, MapViewer
    Location:
    10q26
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (121478330..121598656, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (123237844..123357972, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1153 Neighboring gene uncharacterized LOC105378523 Neighboring gene ribosomal protein S15a pseudogene 5 Neighboring gene arginyltransferase 1 Neighboring gene ATE1 antisense RNA 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Acrocephalosyndactyly type I Compare labs
    Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis Compare labs
    Bent bone dysplasia syndrome
    MedGen: C3281247 OMIM: 614592 GeneReviews: Not available
    Compare labs
    Crouzon syndrome Compare labs
    Cutis Gyrata syndrome of Beare and Stevenson Compare labs
    Isolated coronal synostosis Compare labs
    Jackson-Weiss syndrome Compare labs
    Levy-Hollister syndrome
    MedGen: C0265269 OMIM: 149730 GeneReviews: Not available
    Compare labs
    Neoplasm of stomach
    MedGen: C0038356 OMIM: 613659 GeneReviews: Not available
    Compare labs
    Pfeiffer syndrome Compare labs
    Saethre-Chotzen syndrome
    MedGen: C0175699 OMIM: 101400 GeneReviews: Saethre-Chotzen Syndrome
    Compare labs
    Scaphocephaly, maxillary retrusion, and mental retardation
    MedGen: C1865070 OMIM: 609579 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A combined analysis of genome-wide association studies in breast cancer.
    NHGRI GWA Catalog
    A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese.
    NHGRI GWA Catalog
    A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.
    NHGRI GWA Catalog
    A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.
    NHGRI GWA Catalog
    A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
    NHGRI GWA Catalog
    A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
    NHGRI GWA Catalog
    Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.
    NHGRI GWA Catalog
    Genetic correction of PSA values using sequence variants associated with PSA levels.
    NHGRI GWA Catalog
    Genetic variants associated with breast cancer risk for Ashkenazi Jewish women with strong family histories but no identifiable BRCA1/2 mutation.
    NHGRI GWA Catalog
    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
    NHGRI GWA Catalog
    Genome-wide association study identifies five new breast cancer susceptibility loci.
    NHGRI GWA Catalog
    Genome-wide association study identifies novel breast cancer susceptibility loci.
    NHGRI GWA Catalog
    Genome-wide association study of breast cancer in the Japanese population.
    NHGRI GWA Catalog
    Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
    NHGRI GWA Catalog
    Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
    NHGRI GWA Catalog
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      SHC1 events in ERBB2 signaling, organism-specific biosystemAll ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ERBB4, are able to activate RAF/MAP kinase cascade by recruiting SHC1 (Pinkas-Kramarski et al. 1996, Sepp-Lorenzino et al. 1996) to phosphory...
    • SHC1 events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
      SHC1 events in ERBB4 signaling, organism-specific biosystemAll splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SHC1 (Kaushansky et al. 2008, Pinkas-Kramarski et al. 1996, Cohen et al. 1996). Once bound t...
    • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
      SOS-mediated signalling, organism-specific biosystemSOS is recruited to the plasma membrane and mediates activation of Ras.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
      Signaling Pathways in Glioblastoma, organism-specific biosystemThe most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core p...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
      Signaling by FGFR in disease, organism-specific biosystemA number of skeletal and developmental diseases have been shown to arise as a result of mutations in the FGFR1, 2 and 3 genes. These include dwarfism syndromes (achondroplasia, hypochondroplasia and...
    • Signaling by FGFR1, organism-specific biosystem (from REACTOME)
      Signaling by FGFR1, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR2 amplification mutants, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2 amplification mutants, organism-specific biosystemFGFR2 amplifications have been identified in 10% of gastric cancers, where they are associated with poor prognosis diffuse cancers (Hattori, 1996; Ueda, 1999; Shin, 2000; Kunii, 2008) , and in ~1% of...
    • Signaling by FGFR2 in disease, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2 in disease, organism-specific biosystemThe FGFR2 gene has been shown to be subject to activating mutations and gene amplification leading to a variety of proliferative and developmental disorders depending on whether these events occur in...
    • Signaling by FGFR3, organism-specific biosystem (from REACTOME)
      Signaling by FGFR3, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR4, organism-specific biosystem (from REACTOME)
      Signaling by FGFR4, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by Leptin, organism-specific biosystem (from REACTOME)
      Signaling by Leptin, organism-specific biosystemLeptin (LEP, OB, OBS), a circulating adipokine, and its receptor LEPR (DB, OBR) control food intake and energy balance and are implicated in obesity-related diseases (recently reviewed in Amitani et ...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
      Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Signalling to ERKs, organism-specific biosystem (from REACTOME)
      Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
    • Signalling to RAS, organism-specific biosystem (from REACTOME)
      Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
    • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
      Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ98662

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    fibroblast growth factor-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast growth factor-activated receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fibroblast growth factor-activated receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    bone development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    bone morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    branch elongation involved in salivary gland morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    branching involved in labyrinthine layer morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    branching involved in prostate gland morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    branching involved in salivary gland morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    branching morphogenesis of a nerve ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    bud elongation involved in lung branching ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell-cell signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    coronal suture morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    digestive tract development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    embryonic cranial skeleton morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digestive tract morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    embryonic organ development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    embryonic organ morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    embryonic pattern specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endodermal digestive tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    epidermis morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    epithelial cell proliferation involved in salivary gland morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    fibroblast growth factor receptor signaling pathway involved in hemopoiesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fibroblast growth factor receptor signaling pathway involved in mammary gland specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    gland morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    hair follicle morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    in utero embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    innate immune response TAS
    Traceable Author Statement
    more info
     
    inner ear morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    lacrimal gland development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lateral sprouting from an epithelium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lens fiber cell development IEA
    Inferred from Electronic Annotation
    more info
     
    limb bud formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lung alveolus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lung development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lung lobe morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lung-associated mesenchyme development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mammary gland bud formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membranous septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mesenchymal cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mesenchymal cell differentiation involved in lung development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mesenchymal cell proliferation involved in lung development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mesodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    midbrain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    morphogenesis of embryonic epithelium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    multicellular organism growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
     
    neurotrophin TRK receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    odontogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    orbitofrontal cortex development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    organ growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    organ morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    otic vesicle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    outflow tract septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cardiac muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of epithelial cell proliferation involved in lung morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mesenchymal cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phospholipase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    post-embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    prostate epithelial cord elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    prostate gland morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pyramidal neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of branching involved in prostate gland morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of fibroblast growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of morphogenesis of a branching structure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of multicellular organism growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of osteoblast differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of osteoblast proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of smooth muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    reproductive structure development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    skeletal system morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    squamous basal epithelial stem cell differentiation involved in prostate gland acinus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic vesicle transport IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ventricular cardiac muscle tissue morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ventricular zone neuroblast division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic membrane-bounded vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    excitatory synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    fibroblast growth factor receptor 2
    Names
    BEK fibroblast growth factor receptor
    FGF receptor
    FGFR2-AHCYL1 fusion kinase protein
    bacteria-expressed kinase
    fibroblast growth factor receptor 2 isoform IgIIIc isoform
    hydroxyaryl-protein kinase
    keratinocyte growth factor receptor
    protein tyrosine kinase, receptor like 14
    soluble FGFR4 variant 4
    NP_000132.3
    NP_001138385.1
    NP_001138386.1
    NP_001138387.1
    NP_001138388.1
    NP_001138389.1
    NP_001138390.1
    NP_001138391.1
    NP_075259.4
    NP_075418.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012449.1 RefSeqGene

      Range
      5001..125129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000141.4NP_000132.3  fibroblast growth factor receptor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000132.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1, also referred to as isoform BEK and K-sam.
      Source sequence(s)
      BC037338, BC039243, CB305736, CN345547, CX873387, M87770
      Consensus CDS
      CCDS31298.1
      UniProtKB/Swiss-Prot
      P21802
      Related
      ENSP00000351276, OTTHUMP00000020621, ENST00000358487, OTTHUMT00000050715
      Conserved Domains (7) summary
      cd04973
      Location:47124
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:164248
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:271360
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:173238
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:263359
      IG_like; Immunoglobulin like
      pfam07714
      Location:481757
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:456768
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    2. NM_001144913.1NP_001138385.1  fibroblast growth factor receptor 2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001138385.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate internal in-frame coding exon (as in variant 2), and an alternate 3' terminal exon, compared to transcript variant 1. This results in an isoform (3) with a different, 1 aa longer protein segment in the mid-region, and a novel shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AC009988, AK026508, M97193, U11814, X56191
      Consensus CDS
      CCDS44489.1
      UniProtKB/Swiss-Prot
      P21802
      Related
      ENSP00000358052, OTTHUMP00000020626, ENST00000369056, OTTHUMT00000050720
      Conserved Domains (7) summary
      cd04973
      Location:47124
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd04974
      Location:271358
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:164248
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:173238
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:263357
      IG_like; Immunoglobulin like
      pfam07714
      Location:482758
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:457768
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    3. NM_001144914.1NP_001138386.1  fibroblast growth factor receptor 2 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001138386.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is missing two consecutive in-frame coding exons compared to transcript variant 1. This results in a shorter isoform (4) lacking an internal protein segment compared to isoform 1.
      Source sequence(s)
      AB084153, BC037338, CB305736, M97193, U11814
      Consensus CDS
      CCDS44486.1
      UniProtKB/Swiss-Prot
      P21802
      Related
      ENSP00000358057, ENST00000369061
      Conserved Domains (5) summary
      cd04973
      Location:47124
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:164248
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:173238
      IGc2; Immunoglobulin C-2 Type
      pfam07714
      Location:369645
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:344656
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    4. NM_001144915.1NP_001138387.1  fibroblast growth factor receptor 2 isoform 5 precursor

      See identical proteins and their annotated locations for NP_001138387.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate 5' terminal non-coding exon, and is missing an internal in-frame coding exon, compared to transcript variant 1. This results in a shorter isoform (5) lacking an internal protein segment compared to isoform 1.
      Source sequence(s)
      AK294026, BC037338, CB305736, M87770
      Consensus CDS
      CCDS53584.1
      UniProtKB/Swiss-Prot
      P21802
      Related
      ENSP00000350166, ENST00000357555
      Conserved Domains (6) summary
      cd05857
      Location:75159
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:182271
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:84149
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:174270
      IG_like; Immunoglobulin like
      pfam07714
      Location:392668
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:367679
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    5. NM_001144916.1NP_001138388.1  fibroblast growth factor receptor 2 isoform 6 precursor

      See identical proteins and their annotated locations for NP_001138388.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate 5' terminal exon, and is missing two consecutive in-frame coding exons, compared to transcript variant 1. This results in a shorter isoform (6) lacking an internal protein segment compared to isoform 1.
      Source sequence(s)
      AK308621, BC037338, CB305736, M97193
      UniProtKB/Swiss-Prot
      P21802
      Conserved Domains (6) summary
      cd05857
      Location:49133
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:156245
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:58123
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:148244
      IG_like; Immunoglobulin like
      pfam07714
      Location:366642
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:341653
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    6. NM_001144917.1NP_001138389.1  fibroblast growth factor receptor 2 isoform 7 precursor

      See identical proteins and their annotated locations for NP_001138389.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) is missing two consecutive in-frame coding exons compared to transcript variant 1. This results in a shorter isoform (7) lacking an internal protein segment compared to isoform 1.
      Source sequence(s)
      BC037338, BC039243, CB305736, CN345547, M87771, U11814
      Consensus CDS
      CCDS44487.1
      UniProtKB/Swiss-Prot
      P21802
      Conserved Domains (6) summary
      cd04973
      Location:47124
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:164248
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:173238
      IGc2; Immunoglobulin C-2 Type
      pfam07714
      Location:365641
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:340652
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      cl11960
      Location:271363
      Ig; Immunoglobulin domain
    7. NM_001144918.1NP_001138390.1  fibroblast growth factor receptor 2 isoform 8 precursor

      See identical proteins and their annotated locations for NP_001138390.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) is missing two consecutive in-frame coding exons, and uses an alternate in-frame donor splice site at another coding exon, compared to transcript variant 1. This results in a shorter isoform (8) lacking an internal protein segment and additional 2 aa, compared to isoform 1.
      Source sequence(s)
      BC037338, BC039243, CB305736, CN345547, U11814
      Consensus CDS
      CCDS44485.1
      UniProtKB/Swiss-Prot
      P21802
      Related
      ENSP00000348559, OTTHUMP00000020631, ENST00000356226, OTTHUMT00000050726
      Conserved Domains (6) summary
      cd05857
      Location:49133
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:156245
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:58123
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:148244
      IG_like; Immunoglobulin like
      pfam07714
      Location:364640
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:339651
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    8. NM_001144919.1NP_001138391.1  fibroblast growth factor receptor 2 isoform 9 precursor

      See identical proteins and their annotated locations for NP_001138391.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) is missing an in-frame coding exon, uses an alternate internal in-frame coding exon (as in variant 2) and an alternate 3' terminal exon, compared to transcript variant 1. This results in a shorter isoform (9), which differs in two internal segments, and has a novel C-terminus compared to isoform 1.
      Source sequence(s)
      AC009988, AK026508, BC039243, CN345547, U11814
      Consensus CDS
      CCDS44488.1
      UniProtKB/Swiss-Prot
      P21802
      Related
      ENSP00000353262, OTTHUMP00000020624, ENST00000360144, OTTHUMT00000050718
      Conserved Domains (6) summary
      cd04974
      Location:182269
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:75159
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:84149
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:174268
      IG_like; Immunoglobulin like
      pfam07714
      Location:393669
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:368679
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    9. NM_022970.3NP_075259.4  fibroblast growth factor receptor 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_075259.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate internal in-frame coding exon compared to transcript variant 1, resulting in an isoform (2, also known as isoform K-sam-IIH1, IIIb, and BFR-1) with a different, 1 aa longer protein segment in the mid-region compared to isoform 1.
      Source sequence(s)
      BC037338, BC039243, CB305736, CN345547, M55614, M80634
      Consensus CDS
      CCDS7620.2
      UniProtKB/Swiss-Prot
      P21802
      Conserved Domains (7) summary
      cd04973
      Location:47124
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd04974
      Location:271358
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:164248
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:173238
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:263357
      IG_like; Immunoglobulin like
      pfam07714
      Location:482758
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:457769
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    10. NM_023029.2NP_075418.1  fibroblast growth factor receptor 2 isoform 11 precursor

      See identical proteins and their annotated locations for NP_075418.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks an in-frame coding exon in the 5' region, compared to variant 1. This results in a shorter isoform (11) lacking an internal protein segment compared to isoform 1.
      Source sequence(s)
      AC009988, AK308621, BC039243, CB305736, EF057068
      Consensus CDS
      CCDS73210.1
      UniProtKB/TrEMBL
      D2CGD1
      UniProtKB/Swiss-Prot
      P21802
      Related
      ENSP00000484154, ENST00000613048
      Conserved Domains (6) summary
      cd05857
      Location:75159
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:182271
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:84149
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:174270
      IG_like; Immunoglobulin like
      pfam07714
      Location:392668
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:367679
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

    RNA

    1. NR_073009.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) lacks two consecutive exons in the 5' region and has an additional exon in the center region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB030073, AC009988, BC039243, BC096749, CB305736, M87771, U11814, X52832

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

      Range
      121478330..121598656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717709.2XP_006717772.1  

      See identical proteins and their annotated locations for XP_006717772.1

      UniProtKB/TrEMBL
      D3DRD5
      Conserved Domains (7) summary
      cd04973
      Location:66143
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:183267
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:290379
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:192257
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:282378
      IG_like; Immunoglobulin like
      pfam07714
      Location:498774
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:473785
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    2. XM_006717708.2XP_006717771.1  

      Conserved Domains (7) summary
      cd04973
      Location:66143
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd04974
      Location:290377
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:183267
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:192257
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:282376
      IG_like; Immunoglobulin like
      pfam07714
      Location:499775
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:474786
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    3. XM_006717712.2XP_006717775.1  

      Conserved Domains (6) summary
      cd04974
      Location:175262
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:68152
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:77142
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:167261
      IG_like; Immunoglobulin like
      pfam07714
      Location:386662
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:361673
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    4. XM_006717711.2XP_006717774.1  

      Conserved Domains (6) summary
      cd04974
      Location:201288
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:94178
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:103168
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:193287
      IG_like; Immunoglobulin like
      pfam07714
      Location:412688
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:387699
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    5. XM_011539510.1XP_011537812.1  

      UniProtKB/TrEMBL
      S4R381
      Related
      ENSP00000474011, OTTHUMP00000272645, ENST00000478859, OTTHUMT00000050722
      Conserved Domains (4) summary
      cd05858
      Location:43132
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00410
      Location:35131
      IG_like; Immunoglobulin like
      pfam07714
      Location:253529
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:228540
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    6. XM_006717713.2XP_006717776.1  

      Conserved Domains (7) summary
      cd04973
      Location:66143
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:183267
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:290379
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:192257
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:282378
      IG_like; Immunoglobulin like
      pfam07714
      Location:500776
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:475787
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    7. XM_006717710.2XP_006717773.1  

      Related
      ENSP00000410294, OTTHUMP00000020629, ENST00000457416, OTTHUMT00000050724
      Conserved Domains (7) summary
      cd04973
      Location:66143
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd04974
      Location:290377
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:183267
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:192257
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:282376
      IG_like; Immunoglobulin like
      pfam07714
      Location:501777
      Pkinase_Tyr; Protein tyrosine kinase
      cd05101
      Location:476788
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      123522903..123642701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_022971.1: Suppressed sequence

      Description
      NM_022971.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_022972.1: Suppressed sequence

      Description
      NM_022972.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    3. NM_022973.1: Suppressed sequence

      Description
      NM_022973.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    4. NM_022974.1: Suppressed sequence

      Description
      NM_022974.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    5. NM_022975.2: Suppressed sequence

      Description
      NM_022975.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    6. NM_022976.1: Suppressed sequence

      Description
      NM_022976.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    7. NM_023028.1: Suppressed sequence

      Description
      NM_023028.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    8. NM_023030.1: Suppressed sequence

      Description
      NM_023030.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.