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Dlg1 discs, large homolog 1 (Drosophila) [ Rattus norvegicus (Norway rat) ]

Gene ID: 25252, updated on 19-Jul-2014
Official Symbol
Dlg1provided by RGD
Official Full Name
discs, large homolog 1 (Drosophila)provided by RGD
Primary source
RGD:2505
See related
Ensembl:ENSRNOG00000038597
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Dlgh1; SAP97
Summary
putative cell adhesion molecule, member of the membrane-associated guanylate kinase protein family; binds to NMDA receptors to facilitate NMDA receptor-regulated synapse targeting [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
See Dlg1 in MapViewer
Location:
11q22
Exon count :
27
Annotation release Status Assembly Chr Location
104 current Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (75389409..75454358, complement) , (75239783..75349409, complement)

Chromosome 11 - NC_005110.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549772 Neighboring gene antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 Neighboring gene uncharacterized LOC102549872 Neighboring gene uncharacterized LOC102550676 Neighboring gene uncharacterized LOC102550974

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    T Cell Receptor Signaling Pathway, organism-specific biosystem
    T Cell Receptor Signaling Pathway
  • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • T cell receptor signaling pathway, conserved biosystem (from KEGG)
    T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
L27 domain binding IEA
Inferred from Electronic Annotation
more info
 
L27 domain binding ISO
Inferred from Sequence Orthology
more info
 
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
mitogen-activated protein kinase kinase binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex scaffold IEA
Inferred from Electronic Annotation
more info
 
protein complex scaffold ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
T cell activation IEA
Inferred from Electronic Annotation
more info
 
T cell activation ISO
Inferred from Sequence Orthology
more info
 
T cell cytokine production IEA
Inferred from Electronic Annotation
more info
 
T cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
actin filament organization IEA
Inferred from Electronic Annotation
more info
 
actin filament organization ISO
Inferred from Sequence Orthology
more info
 
actin filament organization ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
amyloid precursor protein metabolic process IEA
Inferred from Electronic Annotation
more info
 
amyloid precursor protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IEP
Inferred from Expression Pattern
more info
PubMed 
cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
cortical actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
hard palate development IEA
Inferred from Electronic Annotation
more info
 
hard palate development ISO
Inferred from Sequence Orthology
more info
 
immunological synapse formation IEA
Inferred from Electronic Annotation
more info
 
immunological synapse formation ISO
Inferred from Sequence Orthology
more info
 
lens development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
lens development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
membrane raft organization IEA
Inferred from Electronic Annotation
more info
 
membrane raft organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
peristalsis IEA
Inferred from Electronic Annotation
more info
 
peristalsis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of establishment of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
positive regulation of establishment of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
positive regulation of potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of potassium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
protein localization ISO
Inferred from Sequence Orthology
more info
 
protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
reproductive structure development IEA
Inferred from Electronic Annotation
more info
 
reproductive structure development ISO
Inferred from Sequence Orthology
more info
 
single organismal cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
single organismal cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
single organismal cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
smooth muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
smooth muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
tight junction assembly IEA
Inferred from Electronic Annotation
more info
 
tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
MPP7-DLG1-LIN7 complex IEA
Inferred from Electronic Annotation
more info
 
MPP7-DLG1-LIN7 complex ISO
Inferred from Sequence Orthology
more info
 
T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
basal lamina ISO
Inferred from Sequence Orthology
more info
 
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell projection membrane IEA
Inferred from Electronic Annotation
more info
 
cell projection membrane ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
immunological synapse IEA
Inferred from Electronic Annotation
more info
 
immunological synapse ISO
Inferred from Sequence Orthology
more info
 
lateral loop IEA
Inferred from Electronic Annotation
more info
 
lateral loop ISO
Inferred from Sequence Orthology
more info
 
lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule ISO
Inferred from Sequence Orthology
more info
 
myelin sheath abaxonal region IEA
Inferred from Electronic Annotation
more info
 
myelin sheath abaxonal region ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
node of Ranvier IEA
Inferred from Electronic Annotation
more info
 
node of Ranvier ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density TAS
Traceable Author Statement
more info
PubMed 
postsynaptic membrane TAS
Traceable Author Statement
more info
PubMed 
presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
 
tight junction IEA
Inferred from Electronic Annotation
more info
 
tight junction ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
disks large homolog 1
Names
disks large homolog 1
SAP-97
synapse-associated protein 97
Drosophila discs-large tumor suppressor homologue (synapse associated protein)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012788.1NP_036920.1  disks large homolog 1

    See proteins identical to NP_036920.1

    Status: PROVISIONAL

    Source sequence(s)
    U14950
    UniProtKB/Swiss-Prot
    Q62696
    Related
    ENSRNOP00000055672, ENSRNOT00000058885
    Conserved Domains (8) summary
    pfam09058
    Location:264
    Blast Score: 319
    L27_1; L27_1
    pfam10608
    Location:106128
    Blast Score: 87
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    cd12031
    Location:581647
    Blast Score: 370
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    COG3087
    Location:72213
    Blast Score: 95
    FtsN; Cell division protein [Cell division and chromosome partitioning]
    cd00071
    Location:723839
    Blast Score: 291
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:224308
    Blast Score: 206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:720898
    Blast Score: 607
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:403464
    Blast Score: 277
    PDZ_assoc; PDZ-associated domain of NMDA receptors

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

  1. NC_005110.3 

    Range
    75239783..75349409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NC_005110.3 

    Range
    75389409..75454358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000079.1 

    Range
    68335260..68524109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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