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dnaA chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948217, updated on 14-Dec-2014
Gene symbol
dnaA
Gene description
chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator
Primary source
EcoGene:EG10235
Locus tag
b3702
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
Also known as
ECK3694; hsm-2; JW3679
Summary
DnaA-ATP is the active form; DnaA-ADP is inactive; switching betwee the two forms modulates initiation activity. [More information is available at EcoGene: EG10235].
Sequence:
NC_000913.3 (3882326..3883729, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene gap repair protein Neighboring gene DNA polymerase III, beta subunit Neighboring gene 50S ribosomal subunit protein L34 Neighboring gene protein C5 component of RNase P Neighboring gene membrane protein insertion efficiency factor, UPF0161 family inner membrane protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Two-component system, organism-specific biosystem (from KEGG)
    Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
  • Two-component system, conserved biosystem (from KEGG)
    Two-component system, conserved biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
Products Interactant Other Gene Complex Source Pubs Description
Names
chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator
NP_418157.1
  • DNA biosynthesis; initiation of chromosome replication; can be transcription regulator

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 

    Range
    3882326..3883729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418157.1 chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator [Escherichia coli str. K-12 substr. MG1655]

    See proteins identical to NP_418157.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03004
    Conserved Domains (5) summary
    cd00009
    Location:147290
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    cd06571
    Location:376465
    Bac_DnaA_C; C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple ...
    PRK00149
    Location:1467
    dnaA; chromosomal replication initiation protein; Reviewed
    pfam11638
    Location:465
    DnaA_N; DnaA N-terminal domain
    cl11404
    Location:77123
    Biotinyl_lipoyl_domains; Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, ...