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Gata3 GATA binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 14462, updated on 5-May-2015
Official Symbol
Gata3provided by MGI
Official Full Name
GATA binding protein 3provided by MGI
Primary source
MGI:MGI:95663
See related
Ensembl:ENSMUSG00000015619; Vega:OTTMUSG00000011129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
jal; Gata-3
Orthologs
See Gata3 in MapViewer
Location:
2 A1; 2 6.69 cM
Exon count:
9
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (9857078..9887950, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (9778705..9800227, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700061F12 gene Neighboring gene predicted gene 13219 Neighboring gene RIKEN cDNA 4930412O13 gene Neighboring gene RIKEN cDNA 9230102O04 gene Neighboring gene predicted gene 13262 Neighboring gene predicted gene, 31290 Neighboring gene TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
E-box binding ISO
Inferred from Sequence Orthology
more info
 
HMG box domain binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enhancer sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-2 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
T cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
T cell differentiation in thymus IGI
Inferred from Genetic Interaction
more info
PubMed 
T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
T-helper 2 cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
anatomical structure formation involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
aortic valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in metanephric kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac right ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate determination IDA
Inferred from Direct Assay
more info
PubMed 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to BMP stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
ear development ISO
Inferred from Sequence Orthology
more info
 
embryonic hemopoiesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
humoral immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
interferon-gamma secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-4 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney development ISO
Inferred from Sequence Orthology
more info
 
lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphocyte migration ISO
Inferred from Sequence Orthology
more info
 
male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mast cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
mesenchymal to epithelial transition ISO
Inferred from Sequence Orthology
more info
 
mesonephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation involved in mesonephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-2 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
nephric duct formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nephric duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
norepinephrine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
otic vesicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
parathyroid gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
parathyroid hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
pharyngeal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-13 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-13 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-4 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-5 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-5 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of thyroid hormone generation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription regulatory region DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ureteric bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
pro-T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of CD4-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular response to X-ray ISO
Inferred from Sequence Orthology
more info
 
regulation of cytokine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of establishment of cell polarity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of histone H3-K27 methylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of histone H3-K4 methylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of nephron tubule epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
renal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
sympathetic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
ureter maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ureteric bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
uterus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
trans-acting T-cell-specific transcription factor GATA-3
Names
trans-acting T-cell-specific transcription factor GATA-3
GATA-binding factor 3
GATA-binding protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008091.3NP_032117.1  trans-acting T-cell-specific transcription factor GATA-3

    See identical proteins and their annotated locations for NP_032117.1

    Status: VALIDATED

    Source sequence(s)
    AA759391, AK090089, AK161099, BC062915
    Consensus CDS
    CCDS15674.1
    UniProtKB/Swiss-Prot
    P23772
    UniProtKB/TrEMBL
    Q3U0R5
    Related
    ENSMUSP00000100041, OTTMUSP00000011932, ENSMUST00000102976, OTTMUST00000026063
    Conserved Domains (1) summary
    cd00202
    Location:316366
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    9857078..9887950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497353.2XP_006497416.1  

    See identical proteins and their annotated locations for XP_006497416.1

    UniProtKB/Swiss-Prot
    P23772
    UniProtKB/TrEMBL
    Q3U0R5
    Conserved Domains (1) summary
    cd00202
    Location:316366
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  2. XM_006497355.2XP_006497418.1  

    Conserved Domains (1) summary
    cd00202
    Location:315365
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  3. XM_006497354.1XP_006497417.1  

    See identical proteins and their annotated locations for XP_006497417.1

    UniProtKB/Swiss-Prot
    P23772
    UniProtKB/TrEMBL
    Q3U0R5
    Conserved Domains (1) summary
    cd00202
    Location:316366
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  4. XM_006497356.2XP_006497419.1  

    Conserved Domains (1) summary
    cd00202
    Location:124174
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    9794542..9816062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)