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    KRT10 keratin 10, type I [ Homo sapiens (human) ]

    Gene ID: 3858, updated on 5-Jul-2015
    Official Symbol
    KRT10provided by HGNC
    Official Full Name
    keratin 10, type Iprovided by HGNC
    Primary source
    HGNC:HGNC:6413
    See related
    Ensembl:ENSG00000186395; HPRD:01021; MIM:148080; Vega:OTTHUMG00000133368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BIE; EHK; K10; KPP; BCIE; CK10
    Summary
    This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
    Orthologs
    See KRT10 in Epigenomics, MapViewer
    Location:
    17q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (40818117..40822618, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38974369..38978863, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371776 Neighboring gene keratin 28, type I Neighboring gene transmembrane protein 99 Neighboring gene uncharacterized LOC105371777 Neighboring gene keratin 12, type I Neighboring gene keratin 20, type I

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    structural constituent of epidermis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intermediate filament NAS
    Non-traceable Author Statement
    more info
    PubMed 
    keratin filament IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    keratin, type I cytoskeletal 10
    Names
    CK-10
    cytokeratin 10
    keratin-10

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008405.1 RefSeqGene

      Range
      5001..9495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000421.3NP_000412.3  keratin, type I cytoskeletal 10

      Status: REVIEWED

      Source sequence(s)
      BC034697, CU455823, M77663
      Consensus CDS
      CCDS11377.1
      UniProtKB/Swiss-Prot
      P13645
      Related
      ENSP00000269576, OTTHUMP00000165049, ENST00000269576, OTTHUMT00000257875
      Conserved Domains (1) summary
      pfam00038
      Location:145454
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      40818117..40822618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257343.2XP_005257400.1  

      Conserved Domains (1) summary
      pfam00038
      Location:145454
      Filament; Intermediate filament protein

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      39209679..39214200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)