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Nos1 nitric oxide synthase 1, neuronal [ Mus musculus (house mouse) ]

Gene ID: 18125, updated on 19-Dec-2014
Official Symbol
Nos1provided by MGI
Official Full Name
nitric oxide synthase 1, neuronalprovided by MGI
Primary source
MGI:MGI:97360
See related
Ensembl:ENSMUSG00000029361; Vega:OTTMUSG00000016286
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NO; bNOS; nNOS; NOS-I; Nos-1; 2310005C01Rik
See Nos1 in Epigenomics, MapViewer
Location:
5 F; 5 57.29 cM
Exon count:
33
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 5 NC_000071.6 (117780979..117958840)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102632031 Neighboring gene kinase suppressor of ras 2 Neighboring gene predicted gene, 30360 Neighboring gene predicted gene, 26995 Neighboring gene F-box protein 21 Neighboring gene tescalcin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATPase binding ISO
Inferred from Sequence Orthology
more info
 
FMN binding ISO
Inferred from Sequence Orthology
more info
 
NADP binding ISO
Inferred from Sequence Orthology
more info
 
NADPH-hemoprotein reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
cadmium ion binding ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
heme binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
arginine catabolic process ISO
Inferred from Sequence Orthology
more info
 
behavioral response to cocaine ISO
Inferred from Sequence Orthology
more info
 
cellular response to epinephrine stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
exogenous drug catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal response to stress ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
negative regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of potassium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of serotonin uptake IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
nitric oxide mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-cysteine S-nitrosylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-cysteine S-nitrosylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of adrenergic receptor signaling pathway involved in heart process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of histone acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of the force of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vasodilation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of vasodilation ISO
Inferred from Sequence Orthology
more info
 
regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to estrogen ISO
Inferred from Sequence Orthology
more info
 
response to heat ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
striated muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
azurophil granule ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
 
vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
nitric oxide synthase, brain
Names
nitric oxide synthase, brain
N-NOS
NC-NOS
NOS type I
neuronal NOS
constitutive NOS
neuronal nitric oxide synthase
peptidyl-cysteine S-nitrosylase NOS1
NP_032738.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008712.2NP_032738.1  nitric oxide synthase, brain

    See proteins identical to NP_032738.1

    Status: PROVISIONAL

    Source sequence(s)
    AC114617, AC114993
    Consensus CDS
    CCDS19606.1
    UniProtKB/Swiss-Prot
    Q9Z0J4
    Related
    ENSMUSP00000127432, ENSMUST00000171055
    Conserved Domains (5) summary
    cd06202
    Location:9961399
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    COG0369
    Location:7541394
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757930
    Flavodoxin_1; Flavodoxin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000071.6 

    Range
    117780979..117958840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530188.1XP_006530251.1  

    See proteins identical to XP_006530251.1

    Conserved Domains (5) summary
    cd06202
    Location:10301433
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    COG0369
    Location:7541428
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757964
    Flavodoxin_1; Flavodoxin
  2. XM_006530187.1XP_006530250.1  

    See proteins identical to XP_006530250.1

    Conserved Domains (5) summary
    cd06202
    Location:10301433
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    COG0369
    Location:7541428
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757964
    Flavodoxin_1; Flavodoxin
  3. XM_006530191.1XP_006530254.1  

    UniProtKB/TrEMBL
    F8WGF2
    Conserved Domains (5) summary
    cd06202
    Location:10301433
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    COG0369
    Location:7541428
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757964
    Flavodoxin_1; Flavodoxin
  4. XM_006530192.1XP_006530255.1  

    Conserved Domains (5) summary
    cd06202
    Location:9961399
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    COG0369
    Location:7541394
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757930
    Flavodoxin_1; Flavodoxin
  5. XM_006530193.1XP_006530256.1  

    See proteins identical to XP_006530256.1

    UniProtKB/Swiss-Prot
    Q9Z0J4
    Related
    ENSMUSP00000120421, OTTMUSP00000017465, ENSMUST00000142742, OTTMUST00000039108
    Conserved Domains (5) summary
    cd06202
    Location:9961399
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    COG0369
    Location:7541394
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757930
    Flavodoxin_1; Flavodoxin
  6. XM_006530189.1XP_006530252.1  

    See proteins identical to XP_006530252.1

    Conserved Domains (5) summary
    cd06202
    Location:10301433
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    COG0369
    Location:7541428
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757964
    Flavodoxin_1; Flavodoxin
  7. XM_006530190.1XP_006530253.1  

    See proteins identical to XP_006530253.1

    Conserved Domains (5) summary
    cd06202
    Location:10301433
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    COG0369
    Location:7541428
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757964
    Flavodoxin_1; Flavodoxin

Alternate Mm_Celera

Genomic

  1. AC_000027.1 

    Range
    114958747..115046830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)