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CHGA chromogranin A [ Homo sapiens (human) ]

Gene ID: 1113, updated on 5-Apr-2015
Official Symbol
CHGAprovided by HGNC
Official Full Name
chromogranin Aprovided by HGNC
Primary source
HGNC:HGNC:1929
See related
Ensembl:ENSG00000100604; HPRD:07170; MIM:118910; Vega:OTTHUMG00000171225
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGA
Summary
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Orthologs
See CHGA in MapViewer
Location:
14q32
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (92922589..92935293)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (93389445..93401638)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370629 Neighboring gene uncharacterized LOC101929002 Neighboring gene inositol-tetrakisphosphate 1-kinase Neighboring gene ITPK1 antisense RNA 1 Neighboring gene cytochrome b5 type A (microsomal) pseudogene 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
defense response to fungus IEA
Inferred from Electronic Annotation
more info
 
innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
killing of cells of other organism IEA
Inferred from Electronic Annotation
more info
 
mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
mast cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
mast cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
mast cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of catecholamine secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dense core granule biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
mast cell granule IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IEA
Inferred from Electronic Annotation
more info
 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
chromogranin-A
Names
chromogranin-A
SP-I
betagranin (N-terminal fragment of chromogranin A)
catestatin
chromofungin
parathyroid secretory protein 1
pituitary secretory protein I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001275.3NP_001266.1  chromogranin-A isoform 1 preproprotein

    See proteins identical to NP_001266.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC001059, BC009384, BX248263, DA201149
    Consensus CDS
    CCDS9906.1
    UniProtKB/Swiss-Prot
    P10645
    UniProtKB/TrEMBL
    Q86T07
    Related
    ENSP00000216492, OTTHUMP00000245492, ENST00000216492, OTTHUMT00000412411
    Conserved Domains (1) summary
    pfam01271
    Location:25457
    Granin; Granin (chromogranin or secretogranin)
  2. NM_001301690.1NP_001288619.1  chromogranin-A isoform 2 preproprotein

    See proteins identical to NP_001288619.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC009384, BX248263, DA201149
    UniProtKB/TrEMBL
    G5E968
    UniProtKB/Swiss-Prot
    P10645
    UniProtKB/TrEMBL
    Q86T07
    Related
    ENSP00000334023, OTTHUMP00000245495, ENST00000334654, OTTHUMT00000412414
    Conserved Domains (1) summary
    pfam01271
    Location:118306
    Granin; Granin (chromogranin or secretogranin)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    92922589..92935293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536370.1XP_011534672.1  

    See proteins identical to XP_011534672.1

    Conserved Domains (1) summary
    pfam01271
    Location:25457
    Granin; Granin (chromogranin or secretogranin)

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    37151..49855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011546640.1XP_011544942.1  

    See proteins identical to XP_011544942.1

    Conserved Domains (1) summary
    pfam01271
    Location:25457
    Granin; Granin (chromogranin or secretogranin)

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    93327694..93339887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)