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IL2 interleukin 2 [ Bos taurus (cattle) ]

Gene ID: 280822, updated on 14-Feb-2015
Official Symbol
IL2
Official Full Name
interleukin 2
See related
BGD:BT12236; Ensembl:ENSBTAG00000020883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
IL-2; TCGF
Orthologs
See IL2 in MapViewer
Location:
chromosome: 17
Exon count:
4
Annotation release Status Assembly Chr Location
104 current Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 17 AC_000174.1 (35618070..35622864)

Chromosome 17 - AC_000174.1Genomic Context describing neighboring genes Neighboring gene interleukin 21 Neighboring gene uncharacterized LOC104974609 Neighboring gene ubiquitin-like modifier-activating enzyme 1 Neighboring gene melanoma antigen preferentially expressed in tumors-like

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-2 receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of lymphocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of immunoglobulin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-17 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of isotype switching to IgG isotypes IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of Stat5 protein IEA
Inferred from Electronic Annotation
more info
 
regulation of T cell homeostatic proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
interleukin-2
Names
interleukin-2
T-cell growth factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_180997.2NP_851340.2  interleukin-2 precursor

    See proteins identical to NP_851340.2

    Status: VALIDATED

    Source sequence(s)
    CB458801, FE004067, FE016063, M12791
    UniProtKB/TrEMBL
    B2BB68
    UniProtKB/Swiss-Prot
    P05016
    Related
    ENSBTAP00000027819, ENSBTAT00000027819
    Conserved Domains (1) summary
    smart00189
    Location:1155
    IL2; Interleukin-2 family

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_taurus_UMD_3.1.1 Primary Assembly

Genomic

  1. AC_000174.1 Reference Bos_taurus_UMD_3.1.1 Primary Assembly

    Range
    35618070..35622864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Btau_4.6.1

Genomic

  1. NC_007315.5 Alternate Btau_4.6.1

    Range
    36455360..36460154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)