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CSF3 colony stimulating factor 3 (granulocyte) [ Homo sapiens (human) ]

Gene ID: 1440, updated on 19-Jul-2014
Official Symbol
CSF3provided by HGNC
Official Full Name
colony stimulating factor 3 (granulocyte)provided by HGNC
Primary source
HGNC:2438
See related
Ensembl:ENSG00000108342; HPRD:00736; MIM:138970; Vega:OTTHUMG00000133247
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCSF; CSF3OS; C17orf33
Summary
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
See CSF3 in Epigenomics, MapViewer
Location:
17q11.2-q12
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (40015361..40017813)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38171614..38174066)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene gasdermin A Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 Neighboring gene uncharacterized LOC102724103 Neighboring gene mediator complex subunit 24 Neighboring gene microRNA 6884 Neighboring gene small nucleolar RNA, C/D box 124

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
NHGRI GWA Catalog
Multiple loci are associated with white blood cell phenotypes.
NHGRI GWA Catalog
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokines and Inflammatory Response, organism-specific biosystem (from WikiPathways)
    Cytokines and Inflammatory Response, organism-specific biosystemInflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an imp...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Malaria, organism-specific biosystem (from KEGG)
    Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Malaria, conserved biosystem (from KEGG)
    Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC45931

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IDA
Inferred from Direct Assay
more info
 
cytokine activity NAS
Non-traceable Author Statement
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
granulocyte colony-stimulating factor receptor binding TAS
Traceable Author Statement
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
granulocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
 
positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
 
positive regulation of protein binding IDA
Inferred from Direct Assay
more info
 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
 
positive regulation of transcription factor import into nucleus IDA
Inferred from Direct Assay
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
granulocyte colony-stimulating factor
Names
granulocyte colony-stimulating factor
filgrastim
lenograstim
pluripoietin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000759.3NP_000750.1  granulocyte colony-stimulating factor isoform a precursor

    See proteins identical to NP_000750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC033245, CB127794, X03438
    Consensus CDS
    CCDS11357.1
    UniProtKB/Swiss-Prot
    P09919
    UniProtKB/TrEMBL
    Q8N4W3
    Related
    ENSP00000225474, OTTHUMP00000164325, ENST00000225474, OTTHUMT00000256988
    Conserved Domains (1) summary
    pfam00489
    Location:51202
    Blast Score: 551
    IL6; Interleukin-6/G-CSF/MGF family
  2. NM_001178147.1NP_001171618.1  granulocyte colony-stimulating factor isoform d precursor

    See proteins identical to NP_001171618.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate, in-frame splice site and lacks an in-frame exon in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform d), compared to isoform a.
    Source sequence(s)
    BC033245, CB127794, X03438
    UniProtKB/Swiss-Prot
    P09919
    UniProtKB/TrEMBL
    Q8N4W3
    Conserved Domains (1) summary
    cl02473
    Location:51163
    Blast Score: 376
    IL6; Interleukin-6/G-CSF/MGF family
  3. NM_172219.2NP_757373.1  granulocyte colony-stimulating factor isoform b precursor

    See proteins identical to NP_757373.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (b).
    Source sequence(s)
    AK313509, BC033245, CB127794, X03655
    Consensus CDS
    CCDS42314.1
    UniProtKB/Swiss-Prot
    P09919
    UniProtKB/TrEMBL
    Q6FH65
    UniProtKB/TrEMBL
    Q8N4W3
    Related
    ENSP00000377705, OTTHUMP00000164327, ENST00000394149, OTTHUMT00000256990
    Conserved Domains (1) summary
    pfam00489
    Location:51199
    Blast Score: 564
    IL6; Interleukin-6/G-CSF/MGF family
  4. NM_172220.2NP_757374.2  granulocyte colony-stimulating factor isoform c precursor

    See proteins identical to NP_757374.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    BC033245, CB127794, CD013926, X03655
    Consensus CDS
    CCDS11358.2
    UniProtKB/Swiss-Prot
    P09919
    UniProtKB/TrEMBL
    Q8N4W3
    Conserved Domains (1) summary
    cl02473
    Location:51166
    Blast Score: 380
    IL6; Interleukin-6/G-CSF/MGF family

RNA

  1. NR_033662.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate segment and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC033245, CB127794, X03438

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    40015361..40017813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    33965611..33968064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    38407306..38409759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)