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    Otc ornithine transcarbamylase [ Mus musculus (house mouse) ]

    Gene ID: 18416, updated on 24-Jun-2016
    Official Symbol
    Otcprovided by MGI
    Official Full Name
    ornithine transcarbamylaseprovided by MGI
    Primary source
    MGI:MGI:97448
    See related
    Ensembl:ENSMUSG00000031173 Vega:OTTMUSG00000016913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sf; spf; AI265390
    Orthologs
    Location:
    X 4.66 cM; X A1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (10252296..10321024)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (9829485..9898150)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33844 Neighboring gene retinitis pigmentosa GTPase regulator Neighboring gene ferritin light chain pseudogene Neighboring gene tetraspanin 7

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (2)  1 citation
    • Radiation induced (1) 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    carboxyl- or carbamoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ornithine carbamoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ornithine carbamoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphate ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ammonia homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    anion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    arginine biosynthetic process via ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    citrulline biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    ornithine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    ornithine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    urea cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    urea cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    ornithine carbamoyltransferase, mitochondrial
    Names
    OTCase
    NP_032795.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008769.4NP_032795.1  ornithine carbamoyltransferase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_032795.1

      Status: VALIDATED

      Source sequence(s)
      AK050930, AL671042, BY090290
      Consensus CDS
      CCDS30015.1
      UniProtKB/Swiss-Prot
      P11725
      UniProtKB/TrEMBL
      Q543H3
      Related
      ENSMUSP00000056152, OTTMUSP00000018384, ENSMUST00000049910, OTTMUST00000041039
      Conserved Domains (3) summary
      PRK00779
      Location:36342
      PRK00779; ornithine carbamoyltransferase; Provisional
      pfam00185
      Location:187341
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam02729
      Location:40182
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      10252296..10321024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247449.2XP_011245751.1  

      See identical proteins and their annotated locations for XP_011245751.1

      UniProtKB/TrEMBL
      Q8R1A8
      Related
      ENSMUSP00000111190, OTTMUSP00000018386
      Conserved Domains (3) summary
      PRK00779
      Location:36330
      PRK00779; ornithine carbamoyltransferase; Provisional
      pfam00185
      Location:187335
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam02729
      Location:40182
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain