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HNRNPL heterogeneous nuclear ribonucleoprotein L [ Homo sapiens (human) ]

Gene ID: 3191, updated on 7-Aug-2014
Official Symbol
HNRNPLprovided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein Lprovided by HGNC
Primary source
HGNC:5045
Locus tag
P/OKcl.14
See related
Ensembl:ENSG00000104824; HPRD:04360; MIM:603083; Vega:OTTHUMG00000182612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNRPL; hnRNP-L; P/OKcl.14
Summary
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
See HNRNPL in Epigenomics, MapViewer
Location:
19q13.2
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (38836388..38852339, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39327028..39342979, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene lectin, galactoside-binding, soluble, 4 Neighboring gene enoyl CoA hydratase 1, peroxisomal Neighboring gene uncharacterized LOC101929424 Neighboring gene Ras and Rab interactor-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heterogeneous nuclear ribonucleoprotein L (HNRNPL) at amino acid residues 392-393 by the HIV-1 protease PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ35509

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA processing TAS
Traceable Author Statement
more info
PubMed 
RNA splicing TAS
Traceable Author Statement
more info
 
gene expression TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
heterogeneous nuclear ribonucleoprotein L
Names
heterogeneous nuclear ribonucleoprotein L
hnRNP L

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005335.1NP_001005335.1  heterogeneous nuclear ribonucleoprotein L isoform b

    See proteins identical to NP_001005335.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AB044547, AK094966, AV743120, BC069184, BI256815, BM997815, BQ334900, X16135
    Consensus CDS
    CCDS33016.1
    UniProtKB/Swiss-Prot
    P14866
    UniProtKB/TrEMBL
    Q6NTA2
    Related
    ENSP00000470231, OTTHUMP00000269658, ENST00000600873, OTTHUMT00000462677
    Conserved Domains (5) summary
    TIGR01649
    Location:1454
    Blast Score: 1886
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    cd12699
    Location:250323
    Blast Score: 413
    RRM3_hnRNPL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cd12704
    Location:366449
    Blast Score: 488
    RRM4_hnRNPL; RNA recognition motif 4 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cd12785
    Location:56155
    Blast Score: 552
    RRM2_hnRNPL; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cl17169
    Location:146
    Blast Score: 270
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001533.2NP_001524.2  heterogeneous nuclear ribonucleoprotein L isoform a

    See proteins identical to NP_001524.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB044547, AK094966, AV743120, BC069184, BI461733, BM997815, BQ334900, X16135
    Consensus CDS
    CCDS33015.1
    UniProtKB/Swiss-Prot
    P14866
    UniProtKB/TrEMBL
    Q6NTA2
    Related
    ENSP00000221419, OTTHUMP00000269655, ENST00000221419, OTTHUMT00000462670
    Conserved Domains (5) summary
    TIGR01649
    Location:100587
    Blast Score: 2044
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    cd12699
    Location:383456
    Blast Score: 416
    RRM3_hnRNPL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cd12704
    Location:499582
    Blast Score: 493
    RRM4_hnRNPL; RNA recognition motif 4 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cd12780
    Location:100179
    Blast Score: 457
    RRM1_hnRNPL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cd12785
    Location:189288
    Blast Score: 563
    RRM2_hnRNPL; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    38836388..38852339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_243927.1 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    35773794..35789557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    39327480..39343450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)