Display Settings:

Format

Send to:

Choose Destination

ANXA5 annexin A5 [ Homo sapiens (human) ]

Gene ID: 308, updated on 21-Jul-2014
Official Symbol
ANXA5provided by HGNC
Official Full Name
annexin A5provided by HGNC
Primary source
HGNC:543
See related
Ensembl:ENSG00000164111; HPRD:00568; MIM:131230; Vega:OTTHUMG00000133034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP4; ANX5; ENX2; RPRGL3; HEL-S-7
Summary
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]
See ANXA5 in Epigenomics, MapViewer
Location:
4q27
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (121667997..121696992, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122589152..122618147, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene KIAA1191 pseudogene Neighboring gene pyroglutamylated RFamide peptide receptor Neighboring gene uncharacterized LOC101927052 Neighboring gene transmembrane protein 155 Neighboring gene uncharacterized LOC100192379 Neighboring gene exosome component 9 Neighboring gene cyclin A2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Pregnancy loss, recurrent, susceptibility to, 3
MedGen: C3280674 OMIM: 614391 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Genome-wide association study of smoking behaviours in patients with COPD.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of annexin A5 (ANXA5) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of annexin A4 and A5 in umbilical cord blood mononuclear cells and T-cell lines but downregulates the expression of annexin A1 in umbilical cord blood mononuclear cells PubMed
Tat tat HIV-1 Tat-induced programmed neuronal cell death involves downregulation of annexin 5 PubMed
tat HIV-1 Tat is strongly associated with ANXA5 in HIV-1-infected lymphocytic cells PubMed
capsid gag HIV-1 CA is strongly associated with ANXA5 in HIV-1-infected lymphocytic cells PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of catalytic activity TAS
Traceable Author Statement
more info
PubMed 
negative regulation of coagulation IEA
Inferred from Electronic Annotation
more info
 
response to organic substance IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
endothelial microparticle IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
annexin A5
Names
annexin A5
CBP-I
PAP-I
VAC-alpha
annexin V
annexin-5
anchorin CII
endonexin II
lipocortin V
calphobindin I
thromboplastin inhibitor
vascular anticoagulant-alpha
epididymis secretory protein Li 7
placental anticoagulant protein 4
placental anticoagulant protein I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032042.1 

    Range
    5001..33996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001154.3NP_001145.1  annexin A5

    See proteins identical to NP_001145.1

    Status: REVIEWED

    Source sequence(s)
    AK312644, BC001429, J03745
    Consensus CDS
    CCDS3720.1
    UniProtKB/Swiss-Prot
    P08758
    UniProtKB/TrEMBL
    V9HWE0
    Related
    ENSP00000296511, OTTHUMP00000164026, ENST00000296511, OTTHUMT00000256636
    Conserved Domains (1) summary
    pfam00191
    Location:2084
    Blast Score: 239
    Annexin; Annexin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    121667997..121696992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    118316005..118345109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    122565582..122594573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)