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    ANPEP alanyl (membrane) aminopeptidase [ Homo sapiens (human) ]

    Gene ID: 290, updated on 5-Jul-2015
    Official Symbol
    ANPEPprovided by HGNC
    Official Full Name
    alanyl (membrane) aminopeptidaseprovided by HGNC
    Primary source
    HGNC:HGNC:500
    See related
    Ensembl:ENSG00000166825; HPRD:01055; MIM:151530; Vega:OTTHUMG00000149814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APN; CD13; LAP1; P150; PEPN; GP150
    Summary
    Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
    Orthologs
    See ANPEP in Epigenomics, MapViewer
    Location:
    15q25-q26
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (89784895..89814854, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90328126..90358119, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L15 pseudogene 1 Neighboring gene mesoderm posterior bHLH transcription factor 2 Neighboring gene uncharacterized LOC105370965 Neighboring gene C15orf38-AP3S2 readthrough Neighboring gene adaptor-related protein complex 3, sigma 2 subunit Neighboring gene microRNA 5094

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    aminopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    metallopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    angiotensin maturation TAS
    Traceable Author Statement
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    aminopeptidase N
    Names
    AP-M
    AP-N
    alanyl aminopeptidase
    aminopeptidase M
    hAPN
    microsomal aminopeptidase
    myeloid plasma membrane glycoprotein CD13
    NP_001141.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001150.2NP_001141.2  aminopeptidase N precursor

      See identical proteins and their annotated locations for NP_001141.2

      Status: REVIEWED

      Source sequence(s)
      AB209918, AC079075, BC058928, BQ879097
      Consensus CDS
      CCDS10356.1
      UniProtKB/TrEMBL
      A0A024RC61
      UniProtKB/Swiss-Prot
      P15144
      UniProtKB/TrEMBL
      Q59E93
      Related
      ENSP00000300060, OTTHUMP00000194690, ENST00000300060, OTTHUMT00000313425
      Conserved Domains (3) summary
      cd09601
      Location:84550
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:75480
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:619942
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

      Range
      89784895..89814854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521473.1XP_011519775.1  

      See identical proteins and their annotated locations for XP_011519775.1

      Conserved Domains (3) summary
      cd09601
      Location:84550
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:75480
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:619942
      ERAP1_C; ERAP1-like C-terminal domain
    2. XM_005254892.3XP_005254949.1  

      See identical proteins and their annotated locations for XP_005254949.1

      UniProtKB/TrEMBL
      A0A024RC61
      UniProtKB/Swiss-Prot
      P15144
      Conserved Domains (3) summary
      cd09601
      Location:84550
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:75480
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:619942
      ERAP1_C; ERAP1-like C-terminal domain
    3. XM_011521474.1XP_011519776.1  

      Conserved Domains (3) summary
      cd09601
      Location:84550
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:75480
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:619670
      ERAP1_C; ERAP1-like C-terminal domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      90169132..90199097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)