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    Nr3c1 nuclear receptor subfamily 3, group C, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 14815, updated on 5-Jul-2015
    Official Symbol
    Nr3c1provided by MGI
    Official Full Name
    nuclear receptor subfamily 3, group C, member 1provided by MGI
    Primary source
    MGI:MGI:95824
    See related
    Ensembl:ENSMUSG00000024431; Vega:OTTMUSG00000023975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GR; Grl1; Grl-1
    Orthologs
    See Nr3c1 in Epigenomics, MapViewer
    Location:
    18 B3; 18 21.09 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 18 NC_000084.6 (39410545..39519416, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (39570199..39646899, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 26 Neighboring gene predicted gene, 30572 Neighboring gene predicted gene 15337 Neighboring gene predicted gene, 30909 Neighboring gene predicted gene, 30961

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    glucocorticoid receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein dimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    steroid binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adrenal gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to dexamethasone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to steroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin-mediated maintenance of transcription ISO
    Inferred from Sequence Orthology
    more info
     
    glucocorticoid mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    glucocorticoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucocorticoid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucocorticoid receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucocorticoid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    mammary gland duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maternal behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of glucocorticoid mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucocorticoid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glucocorticoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    response to arsenic-containing substance ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    glucocorticoid receptor
    Names
    glucocorticoid receptor 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008173.3NP_032199.3  glucocorticoid receptor

      See identical proteins and their annotated locations for NP_032199.3

      Status: VALIDATED

      Source sequence(s)
      AA124418, AK037733, AK171439, BQ176909, BY232938, CN720992
      Consensus CDS
      CCDS37791.1
      UniProtKB/TrEMBL
      E9PUR6
      Related
      ENSMUSP00000111233, ENSMUST00000115571
      Conserved Domains (3) summary
      cd07076
      Location:546792
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:433510
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27418
      GCR; Glucocorticoid receptor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p3 C57BL/6J

      Range
      39410545..39519416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525662.1XP_006525725.1  

      See identical proteins and their annotated locations for XP_006525725.1

      UniProtKB/TrEMBL
      E9PYV1
      Conserved Domains (3) summary
      cd07076
      Location:547793
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:433511
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27418
      GCR; Glucocorticoid receptor
    2. XM_006525661.2XP_006525724.1  

      See identical proteins and their annotated locations for XP_006525724.1

      UniProtKB/TrEMBL
      E9PYV1
      Conserved Domains (3) summary
      cd07076
      Location:547793
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:433511
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27418
      GCR; Glucocorticoid receptor
    3. XM_006525664.1XP_006525727.1  

      See identical proteins and their annotated locations for XP_006525727.1

      UniProtKB/TrEMBL
      E9PYV1
      Conserved Domains (3) summary
      cd07076
      Location:547793
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:433511
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27418
      GCR; Glucocorticoid receptor
    4. XM_006525659.2XP_006525722.1  

      See identical proteins and their annotated locations for XP_006525722.1

      UniProtKB/TrEMBL
      E9PYV1
      Conserved Domains (3) summary
      cd07076
      Location:547793
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:433511
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27418
      GCR; Glucocorticoid receptor
    5. XM_006525663.2XP_006525726.1  

      See identical proteins and their annotated locations for XP_006525726.1

      UniProtKB/TrEMBL
      E9PYV1
      Conserved Domains (3) summary
      cd07076
      Location:547793
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:433511
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27418
      GCR; Glucocorticoid receptor
    6. XM_006525665.2XP_006525728.1  

      See identical proteins and their annotated locations for XP_006525728.1

      UniProtKB/TrEMBL
      E9PYV1
      Conserved Domains (3) summary
      cd07076
      Location:547793
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:433511
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27418
      GCR; Glucocorticoid receptor
    7. XM_006525658.1XP_006525721.1  

      See identical proteins and their annotated locations for XP_006525721.1

      UniProtKB/TrEMBL
      E9PYV1
      Conserved Domains (3) summary
      cd07076
      Location:547793
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:433511
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27418
      GCR; Glucocorticoid receptor
    8. XM_006525666.2XP_006525729.1  

      See identical proteins and their annotated locations for XP_006525729.1

      UniProtKB/TrEMBL
      E9PUR6
      Conserved Domains (3) summary
      cd07076
      Location:546792
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:433510
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27418
      GCR; Glucocorticoid receptor
    9. XM_006525660.1XP_006525723.1  

      See identical proteins and their annotated locations for XP_006525723.1

      UniProtKB/TrEMBL
      E9PYV1
      Conserved Domains (3) summary
      cd07076
      Location:547793
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:433511
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27418
      GCR; Glucocorticoid receptor

    Alternate Mm_Celera

    Genomic

    1. AC_000040.1 Alternate Mm_Celera

      Range
      40761405..40838026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)