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    Ogg1 8-oxoguanine DNA-glycosylase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18294, updated on 24-Jun-2016
    Official Symbol
    Ogg1provided by MGI
    Official Full Name
    8-oxoguanine DNA-glycosylase 1provided by MGI
    Primary source
    MGI:MGI:1097693
    See related
    Ensembl:ENSMUSG00000030271 Vega:OTTMUSG00000022453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mmh
    Orthologs
    Location:
    6 52.75 cM; 6 E-F1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (113326976..113334188)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (113276970..113284182)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene copine family member IX Neighboring gene bromodomain and PHD finger containing, 1 Neighboring gene calcium/calmodulin-dependent protein kinase I Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene Neighboring gene transcriptional adaptor 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA N-glycosylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA N-glycosylase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA-(apurinic or apyrimidinic site) lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-3-methylbase glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    deoxyribonucleoside 5'-monophosphate N-glycosidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nicotinamide riboside hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nicotinic acid riboside hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidized base lesion DNA N-glycosylase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    oxidized purine DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidized purine nucleobase lesion DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidized purine nucleobase lesion DNA N-glycosylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidized purine nucleobase lesion DNA N-glycosylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    purine-specific mismatch base pair DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    single-strand selective uracil DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    uracil DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aging ISO
    Inferred from Sequence Orthology
    more info
     
    base-excision repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    base-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of double-strand break repair via single-strand annealing ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide-excision repair, DNA incision ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    response to estradiol ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to radiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    N-glycosylase/DNA lyase
    NP_035087.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010957.4NP_035087.3  N-glycosylase/DNA lyase

      See identical proteins and their annotated locations for NP_035087.3

      Status: VALIDATED

      Source sequence(s)
      AK146870, Y11247
      Consensus CDS
      CCDS20414.1
      UniProtKB/Swiss-Prot
      O08760
      UniProtKB/TrEMBL
      Q3UIL3
      Related
      ENSMUSP00000032406, OTTMUSP00000025541, ENSMUST00000032406, OTTMUST00000053690
      Conserved Domains (3) summary
      TIGR00588
      Location:11328
      ogg; 8-oxoguanine DNA-glycosylase (ogg)
      cd00056
      Location:139319
      ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
      pfam07934
      Location:25141
      OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      113326976..113334188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505720.1XP_006505783.1  

      Conserved Domains (2) summary
      cd00056
      Location:32212
      ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
      cl05528
      Location:2234
      AlkA_N; AlkA N-terminal domain
    2. XM_006505721.1XP_006505784.1  

      See identical proteins and their annotated locations for XP_006505784.1

      Conserved Domains (2) summary
      cd00056
      Location:28208
      ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
      cl05528
      Location:1830
      AlkA_N; AlkA N-terminal domain
    3. XM_006505722.1XP_006505785.1  

      See identical proteins and their annotated locations for XP_006505785.1

      Conserved Domains (2) summary
      cd00056
      Location:28208
      ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
      cl05528
      Location:1830
      AlkA_N; AlkA N-terminal domain