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    Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like [ Mus musculus (house mouse) ]

    Gene ID: 270685, updated on 8-Aug-2016
    Official Symbol
    Mthfd1lprovided by MGI
    Official Full Name
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-likeprovided by MGI
    Primary source
    MGI:MGI:1924836
    See related
    Ensembl:ENSMUSG00000040675 Vega:OTTMUSG00000029856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI647056; Fthfsdc1; 2410004L15Rik
    Orthologs
    Location:
    10; 10 A1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (3972782..4167081)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (6179460..6373466, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 1 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene ring finger protein 4 pseudogene Neighboring gene predicted gene, 40591 Neighboring gene predicted gene, 30570 Neighboring gene A kinase (PRKA) anchor protein (gravin) 12 Neighboring gene predicted gene, 40592

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    formate-tetrahydrofolate ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    formate-tetrahydrofolate ligase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    10-formyltetrahydrofolate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    embryonic neurocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    folic acid-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    folic acid-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    formate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    tetrahydrofolate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Names
    formyltetrahydrofolate synthetase domain containing 1
    NP_001164256.1
    NP_001164257.1
    NP_758512.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170785.1NP_001164256.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001164256.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC153570, AC159148, AK036284
      Consensus CDS
      CCDS56672.1
      UniProtKB/Swiss-Prot
      Q3V3R1
      Related
      ENSMUSP00000112897, OTTMUSP00000038449, ENSMUST00000120585, OTTMUST00000074098
      Conserved Domains (4) summary
      PLN02759
      Location:351977
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:82287
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:73179
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      pfam02882
      Location:182337
      THF_DHG_CYH_C; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
    2. NM_001170786.1NP_001164257.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001164257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC153570, AC159148, AK160025
      Consensus CDS
      CCDS56672.1
      UniProtKB/Swiss-Prot
      Q3V3R1
      Related
      ENSMUSP00000036178, OTTMUSP00000038448, ENSMUST00000043735, OTTMUST00000074097
      Conserved Domains (4) summary
      PLN02759
      Location:351977
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:82287
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:73179
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      pfam02882
      Location:182337
      THF_DHG_CYH_C; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
    3. NM_172308.4NP_758512.3  monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_758512.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC153570, AC159148, AK028211
      Consensus CDS
      CCDS56672.1
      UniProtKB/Swiss-Prot
      Q3V3R1
      Related
      ENSMUSP00000112870, OTTMUSP00000038447, ENSMUST00000117291, OTTMUST00000074096
      Conserved Domains (4) summary
      PLN02759
      Location:351977
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:82287
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:73179
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      pfam02882
      Location:182337
      THF_DHG_CYH_C; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      3972782..4167081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512449.3XP_006512512.1  

      Conserved Domains (4) summary
      COG0190
      Location:82287
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:73179
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      pfam02882
      Location:182337
      THF_DHG_CYH_C; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
      cl21455
      Location:351707
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases