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    STAU2 staufen double-stranded RNA binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 27067, updated on 8-Aug-2016
    Official Symbol
    STAU2provided by HGNC
    Official Full Name
    staufen double-stranded RNA binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:11371
    See related
    Ensembl:ENSG00000040341 HPRD:09328; MIM:605920; Vega:OTTHUMG00000164499
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    39K2; 39K3
    Summary
    Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
    Orthologs
    Location:
    8q21.11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (73420369..73747708, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (74332604..74659943, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RDH10 antisense RNA 1 Neighboring gene retinol dehydrogenase 10 (all-trans) Neighboring gene uncharacterized LOC105375899 Neighboring gene STAU2 antisense RNA 1 Neighboring gene uncharacterized LOC105375902 Neighboring gene VENT homeobox pseudogene 6 Neighboring gene ubiquitin conjugating enzyme E2 W (putative) Neighboring gene RNA, 7SL, cytoplasmic 760, pseudogene Neighboring gene long intergenic non-protein coding RNA 1617 Neighboring gene glycogenin 1 pseudogene 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with staufen is mediated by staufen's dsRBD3 domain PubMed
    gag Staufen is incorporated into HIV-1 virions through association with HIV-1 genomic RNA and is implicated in HIV-1 genome selection and packaging into assembling virions, a process that is mediated by the Nucleocapsid domain of HIV-1 Gag PubMed
    Rev rev HIV-1 Rev interacts with human STAU-2 protein in a RNA-independent manner and influences the sub-cellular localization of STAU-2. HIV-1 infection upregulates STAU-2 expression in human T-lymphocytes and astrocytes PubMed
    capsid gag Human STAU-2 increases HIV-1 production with upregulated levels of HIV-1 CA PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC119606, DKFZp781K0371

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    double-stranded RNA-binding protein Staufen homolog 2
    Names
    staufen homolog 2
    staufen, RNA binding protein, homolog 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164380.1NP_001157852.1  double-stranded RNA-binding protein Staufen homolog 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest isoform (a).
      Source sequence(s)
      AC100784, AF459097, AK002152, DB501161
      Consensus CDS
      CCDS55247.1
      UniProtKB/Swiss-Prot
      Q9NUL3
      UniProtKB/TrEMBL
      A0A0A0MTC5
      Related
      ENSP00000428756, OTTHUMP00000226833, ENST00000524300, OTTHUMT00000379000
      Conserved Domains (2) summary
      smart00358
      Location:308374
      DSRM; Double-stranded RNA binding motif
      pfam16482
      Location:459523
      Staufen_C; Staufen C-terminal domain
    2. NM_001164381.1NP_001157853.1  double-stranded RNA-binding protein Staufen homolog 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC100784, AF459097, BC008369, DB501161
      Consensus CDS
      CCDS55248.1
      UniProtKB/Swiss-Prot
      Q9NUL3
      UniProtKB/TrEMBL
      E9PH62
      Related
      ENSP00000428456, OTTHUMP00000226832, ENST00000522695, OTTHUMT00000378999
      Conserved Domains (2) summary
      smart00358
      Location:276342
      DSRM; Double-stranded RNA binding motif
      pfam16482
      Location:427491
      Staufen_C; Staufen C-terminal domain
    3. NM_001164382.1NP_001157854.1  double-stranded RNA-binding protein Staufen homolog 2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AC100784, AF459097, AK002152, AK303104, DB501161
      Consensus CDS
      CCDS55245.1
      UniProtKB/Swiss-Prot
      Q9NUL3
      UniProtKB/TrEMBL
      A0A0A0MTC6
      Related
      ENSP00000429173, OTTHUMP00000226835, ENST00000521210, OTTHUMT00000379002
      Conserved Domains (3) summary
      smart00358
      Location:204270
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:3775
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:355457
      Staufen_C; Staufen C-terminal domain
    4. NM_001164383.1NP_001157855.1  double-stranded RNA-binding protein Staufen homolog 2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AC100784, AF459097, AK002152, AK293496, DB501161
      Consensus CDS
      CCDS55244.1
      UniProtKB/Swiss-Prot
      Q9NUL3
      UniProtKB/TrEMBL
      A0A0A0MTC4
      Related
      ENSP00000428741, OTTHUMP00000226834, ENST00000523558, OTTHUMT00000379001
      Conserved Domains (2) summary
      smart00358
      Location:136202
      DSRM; Double-stranded RNA binding motif
      pfam16482
      Location:287351
      Staufen_C; Staufen C-terminal domain
    5. NM_001164384.1NP_001157856.1  double-stranded RNA-binding protein Staufen homolog 2 isoform e

      See identical proteins and their annotated locations for NP_001157856.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' and 3' UTRs and coding sequence compared to variant 1. The resulting isoform (e) has shorter and distinct N- and C-termini compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
      Source sequence(s)
      AB210014, AK001576, AK023314, AK290141, CA311807, Y19062
      Consensus CDS
      CCDS6214.1
      UniProtKB/Swiss-Prot
      Q9NUL3
      UniProtKB/TrEMBL
      A8K276, F8VPI7, Q4LE57
      Related
      ENSP00000427977, OTTHUMP00000226841, ENST00000522509, OTTHUMT00000379008
      Conserved Domains (1) summary
      cd00048
      Location:275341
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    6. NM_001164385.1NP_001157857.1  double-stranded RNA-binding protein Staufen homolog 2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AB210014, AK001576, AK023314, AK294466, CA311807, DB501161
      Consensus CDS
      CCDS55246.1
      UniProtKB/Swiss-Prot
      Q9NUL3
      UniProtKB/TrEMBL
      A0A0A0MTD1, Q4LE57
      Related
      ENSP00000431111, OTTHUMP00000226840, ENST00000517542, OTTHUMT00000379007
      Conserved Domains (2) summary
      smart00358
      Location:270336
      DSRM; Double-stranded RNA binding motif
      pfam16482
      Location:421473
      Staufen_C; Staufen C-terminal domain
    7. NM_014393.2NP_055208.2  double-stranded RNA-binding protein Staufen homolog 2 isoform e

      See identical proteins and their annotated locations for NP_055208.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and coding sequence compared to variant 1. The resulting isoform (e) has shorter and distinct N- and C-termini compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
      Source sequence(s)
      AB210014, AK001576, AK023314, CA311807, DB501161, Y19062
      Consensus CDS
      CCDS6214.1
      UniProtKB/Swiss-Prot
      Q9NUL3
      UniProtKB/TrEMBL
      F8VPI7, Q4LE57
      Related
      ENSP00000348026, OTTHUMP00000226836, ENST00000355780, OTTHUMT00000379003
      Conserved Domains (1) summary
      cd00048
      Location:275341
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      73420369..73747708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      74385185..74712036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)