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    Vcam1 vascular cell adhesion molecule 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25361, updated on 19-Jan-2016
    Official Symbol
    Vcam1provided by RGD
    Official Full Name
    vascular cell adhesion molecule 1provided by RGD
    Primary source
    RGD:3952
    See related
    Ensembl:ENSRNOG00000014333
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    VCAM1B
    Summary
    binds integrin very late antigen (VLA4); plays a role in cell adhesion [RGD, Feb 2006]
    Orthologs
    See Vcam1 in MapViewer
    Location:
    2q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219071193..219090931, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (237158192..237177779, complement)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene similar to 60S ribosomal protein L13 Neighboring gene ribosomal protein S27a, pseudogene 24 Neighboring gene vascular cell adhesion protein 1-like Neighboring gene G-protein coupled receptor 88

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • African trypanosomiasis, organism-specific biosystem (from KEGG)
      African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • African trypanosomiasis, conserved biosystem (from KEGG)
      African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • TNF signaling pathway, organism-specific biosystem (from KEGG)
      TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TNF signaling pathway, conserved biosystem (from KEGG)
      TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...

    Markers

    Homology

    Clone Names

    • MGC108734

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    primary amine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    primary amine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acute inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    amine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    amine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-mediated signaling using intracellular calcium source IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-mediated signaling using intracellular calcium source ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to vascular endothelial growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    chorio-allantoic fusion IEA
    Inferred from Electronic Annotation
    more info
     
    chorio-allantoic fusion ISO
    Inferred from Sequence Orthology
    more info
     
    chronic inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    embryonic placenta morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte tethering or rolling IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    membrane to membrane docking IEA
    Inferred from Electronic Annotation
    more info
     
    membrane to membrane docking ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ionizing radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nicotine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    single organismal cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    microvillus IEA
    Inferred from Electronic Annotation
    more info
     
    microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    podosome IEA
    Inferred from Electronic Annotation
    more info
     
    podosome ISO
    Inferred from Sequence Orthology
    more info
     
    sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    vascular cell adhesion protein 1
    Names
    V-CAM 1
    VCAM-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012889.1NP_037021.1  vascular cell adhesion protein 1 precursor

      See identical proteins and their annotated locations for NP_037021.1

      Status: PROVISIONAL

      Source sequence(s)
      M84488
      UniProtKB/Swiss-Prot
      P29534
      Related
      ENSRNOP00000019377, ENSRNOT00000019377
      Conserved Domains (6) summary
      cd00096
      Location:530593
      Ig; Immunoglobulin domain
      cd07689
      Location:404502
      Ig2_VCAM-1; Second immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      smart00408
      Location:238298
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:609685
      IG; Immunoglobulin
      smart00410
      Location:321400
      IG_like; Immunoglobulin like
      cl11960
      Location:234309
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      219071193..219090931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      196537457..196557044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)