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PIWIL2 piwi-like RNA-mediated gene silencing 2 [ Homo sapiens (human) ]

Gene ID: 55124, updated on 9-Dec-2014
Official Symbol
PIWIL2provided by HGNC
Official Full Name
piwi-like RNA-mediated gene silencing 2provided by HGNC
Primary source
HGNC:HGNC:17644
See related
Ensembl:ENSG00000197181; HPRD:11434; MIM:610312; Vega:OTTHUMG00000097767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT80; HILI; mili; PIWIL1L
Summary
PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]
See PIWIL2 in Epigenomics, MapViewer
Location:
8p21.3
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (22275297..22357568)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22132810..22215560)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507071 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide D, 44kDa Neighboring gene solute carrier family 39 (zinc transporter), member 14 Neighboring gene ribosomal protein L21 pseudogene 77 Neighboring gene protein phosphatase 3, catalytic subunit, gamma isozyme Neighboring gene basic transcription factor 3, pseudogene 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10351, MGC133049

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA binding IEA
Inferred from Electronic Annotation
more info
 
piRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
piRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
DNA methylation involved in gamete generation ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA 5'-end processing ISS
Inferred from Sequence or Structural Similarity
more info
 
gene silencing by RNA ISS
Inferred from Sequence or Structural Similarity
more info
 
germ-line stem cell maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
oogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
piRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of meiosis I IEA
Inferred from Electronic Annotation
more info
 
positive regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
P granule ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatoid body ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
pi-body ISS
Inferred from Sequence or Structural Similarity
more info
 
polysome IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
piwi-like protein 2
Names
piwi-like protein 2
Miwi like
piwi-like 2
piwil2-like protein
cancer/testis antigen 80
80kDa PIWIL2 short isoform

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135721.1NP_001129193.1  piwi-like protein 2

    See proteins identical to NP_001129193.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AB079367, AK292440, DC403636
    Consensus CDS
    CCDS6029.1
    UniProtKB/Swiss-Prot
    Q8TC59
    UniProtKB/TrEMBL
    W0HK13
    Related
    ENSP00000406956, OTTHUMP00000224869, ENST00000454009, OTTHUMT00000375438
    Conserved Domains (3) summary
    cd02845
    Location:387504
    PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...
    cd04658
    Location:512956
    Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...
    pfam08699
    Location:338386
    DUF1785; Domain of unknown function (DUF1785)
  2. NM_018068.3NP_060538.2  piwi-like protein 2

    See proteins identical to NP_060538.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AB079367, AK315830
    Consensus CDS
    CCDS6029.1
    UniProtKB/Swiss-Prot
    Q8TC59
    UniProtKB/TrEMBL
    W0HK13
    Related
    ENSP00000428267, OTTHUMP00000224868, ENST00000521356, OTTHUMT00000375437
    Conserved Domains (3) summary
    cd02845
    Location:387504
    PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...
    cd04658
    Location:512956
    Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...
    pfam08699
    Location:338386
    DUF1785; Domain of unknown function (DUF1785)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 

    Range
    22275297..22357568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273550.2XP_005273607.1  

    See proteins identical to XP_005273607.1

    UniProtKB/Swiss-Prot
    Q8TC59
    Related
    ENSP00000349208, OTTHUMP00000123401, ENST00000356766, OTTHUMT00000215006
    Conserved Domains (3) summary
    cd02845
    Location:387504
    PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...
    cd04658
    Location:512920
    Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...
    pfam08699
    Location:338386
    DUF1785; Domain of unknown function (DUF1785)
  2. XM_005273551.1XP_005273608.1  

    Conserved Domains (3) summary
    cd02845
    Location:387504
    PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...
    cd04658
    Location:512802
    Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...
    pfam08699
    Location:338386
    DUF1785; Domain of unknown function (DUF1785)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 

    Range
    22334485..22415561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000140.1 

    Range
    20675010..20755706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)