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Pomc pro-opiomelanocortin-alpha [ Mus musculus (house mouse) ]

Gene ID: 18976, updated on 19-Jul-2014
Official Symbol
Pomcprovided by MGI
Official Full Name
pro-opiomelanocortin-alphaprovided by MGI
Primary source
MGI:97742
See related
Ensembl:ENSMUSG00000020660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BE; Npp; ACTH; Clip; Pomc1; Pomc-1; Beta-LPH; alphaMSH; beta-MSH; Gamma-LPH; alpha-MSH; gamma-MSH
Summary
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing. Processing yields several biologically active peptides, which are involved in diverse cellular functions, such as energy homeostasis, steroidogenesis, and increased melanin production in melanocytes. In mouse deficiency of this gene is associated with obesity, defects in adrenal development, and altered pigmentation. A pseudogene of this gene is located on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
See Pomc in Epigenomics, MapViewer
Location:
12 A1.1; 12 1.99 cM
Exon count:
5
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 12 NC_000078.6 (3954945..3960643)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 3A Neighboring gene uncharacterized LOC102633913 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene EFR3 homolog B (S. cerevisiae) Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 27

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
hormone activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
type 1 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
 
type 3 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
 
type 4 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
cellular pigmentation ISO
Inferred from Sequence Orthology
more info
 
generation of precursor metabolites and energy ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of appetite ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of corticosterone secretion IMP
Inferred from Mutant Phenotype
more info
 
regulation of glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
pro-opiomelanocortin
Names
pro-opiomelanocortin
beta-endorphin
met-enkephalin
melanotropin gamma
corticotropin-lipotropin
adrenocorticotropic hormone
adrenal corticotropic hormone
alpha-melanocyte stimulating hormone
corticotropin-like intermediary peptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278581.1NP_001265510.1  pro-opiomelanocortin preproprotein

    See proteins identical to NP_001265510.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AC111092, AW120866, BB022229, BB022936, BB025409, BB026464
    Consensus CDS
    CCDS25785.1
    UniProtKB/Swiss-Prot
    P01193
    Conserved Domains (3) summary
    pfam08384
    Location:2771
    Blast Score: 201
    NPP; Pro-opiomelanocortin, N-terminal region
    pfam00976
    Location:124162
    Blast Score: 201
    ACTH_domain; Corticotropin ACTH domain
    pfam08035
    Location:205233
    Blast Score: 127
    Op_neuropeptide; Opioids neuropeptide
  2. NM_001278582.1NP_001265511.1  pro-opiomelanocortin preproprotein

    See proteins identical to NP_001265511.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AC111092, AW120866, BB022229, BB022936, BB025409, BB026464
    Consensus CDS
    CCDS25785.1
    UniProtKB/Swiss-Prot
    P01193
    Conserved Domains (3) summary
    pfam08384
    Location:2771
    Blast Score: 201
    NPP; Pro-opiomelanocortin, N-terminal region
    pfam00976
    Location:124162
    Blast Score: 201
    ACTH_domain; Corticotropin ACTH domain
    pfam08035
    Location:205233
    Blast Score: 127
    Op_neuropeptide; Opioids neuropeptide
  3. NM_001278583.1NP_001265512.1  pro-opiomelanocortin preproprotein

    See proteins identical to NP_001265512.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AC111092, AK030714, BB022936, BB025409, BB026464
    Consensus CDS
    CCDS25785.1
    UniProtKB/Swiss-Prot
    P01193
    Conserved Domains (3) summary
    pfam08384
    Location:2771
    Blast Score: 201
    NPP; Pro-opiomelanocortin, N-terminal region
    pfam00976
    Location:124162
    Blast Score: 201
    ACTH_domain; Corticotropin ACTH domain
    pfam08035
    Location:205233
    Blast Score: 127
    Op_neuropeptide; Opioids neuropeptide
  4. NM_001278584.1NP_001265513.1  pro-opiomelanocortin preproprotein

    See proteins identical to NP_001265513.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AC111092, AK017581, BB025409, BB026464
    Consensus CDS
    CCDS25785.1
    UniProtKB/Swiss-Prot
    P01193
    Conserved Domains (3) summary
    pfam08384
    Location:2771
    Blast Score: 201
    NPP; Pro-opiomelanocortin, N-terminal region
    pfam00976
    Location:124162
    Blast Score: 201
    ACTH_domain; Corticotropin ACTH domain
    pfam08035
    Location:205233
    Blast Score: 127
    Op_neuropeptide; Opioids neuropeptide
  5. NM_008895.4NP_032921.1  pro-opiomelanocortin preproprotein

    See proteins identical to NP_032921.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AC111092, AK017492, AK133646, BB025409
    Consensus CDS
    CCDS25785.1
    UniProtKB/Swiss-Prot
    P01193
    Related
    ENSMUSP00000020990, ENSMUST00000020990
    Conserved Domains (3) summary
    pfam08384
    Location:2771
    Blast Score: 201
    NPP; Pro-opiomelanocortin, N-terminal region
    pfam00976
    Location:124162
    Blast Score: 201
    ACTH_domain; Corticotropin ACTH domain
    pfam08035
    Location:205233
    Blast Score: 127
    Op_neuropeptide; Opioids neuropeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000078.6 

    Range
    3954945..3960643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000034.1 

    Range
    3882688..3888382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)