Display Settings:

Format

Send to:

Choose Destination

DGKQ diacylglycerol kinase, theta 110kDa [ Homo sapiens (human) ]

Gene ID: 1609, updated on 26-Aug-2014
Official Symbol
DGKQprovided by HGNC
Official Full Name
diacylglycerol kinase, theta 110kDaprovided by HGNC
Primary source
HGNC:2856
See related
Ensembl:ENSG00000145214; HPRD:03127; MIM:601207; Vega:OTTHUMG00000088629
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAGK; DAGK4; DAGK7
Summary
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]
See DGKQ in Epigenomics, MapViewer
Location:
4p16.3
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (958884..973560, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (952672..967348, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene cyclin G associated kinase Neighboring gene transmembrane protein 175 Neighboring gene solute carrier family 26 (anion exchanger), member 1 Neighboring gene iduronidase, alpha-L- Neighboring gene fibroblast growth factor receptor-like 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
NHGRI GWA Catalog
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
NHGRI GWA Catalog
Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
NHGRI GWA Catalog
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
 
cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
protein kinase C signaling IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase C-activating G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
response to ATP IDA
Inferred from Direct Assay
more info
PubMed 
thrombin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
diacylglycerol kinase theta
Names
diacylglycerol kinase theta
DGK-theta
DAG kinase theta
diglyceride kinase theta
NP_001338.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347.3NP_001338.2  diacylglycerol kinase theta

    See proteins identical to NP_001338.2

    Status: REVIEWED

    Source sequence(s)
    AB209503, AC019103, AW139889, BC063801, DN990411
    Consensus CDS
    CCDS3342.1
    UniProtKB/Swiss-Prot
    P52824
    UniProtKB/TrEMBL
    Q59FF7
    Related
    ENSP00000273814, OTTHUMP00000112179, ENST00000273814, OTTHUMT00000200888
    Conserved Domains (6) summary
    cd01783
    Location:395492
    Blast Score: 419
    DAGK_delta_RA; Ubiquitin-like domain of Diacylgylcerol kinase (DAGK)
    smart00045
    Location:741893
    Blast Score: 610
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:590714
    Blast Score: 429
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:61108
    Blast Score: 152
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00788
    Location:299352
    Blast Score: 98
    RA; Ras association (RalGDS/AF-6) domain
    cl00040
    Location:122168
    Blast Score: 92
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    958884..973560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713863.1XP_006713926.1  

    Conserved Domains (4) summary
    cd00029
    Location:61108
    Blast Score: 136
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00788
    Location:299352
    Blast Score: 98
    RA; Ras association (RalGDS/AF-6) domain
    cl00040
    Location:122168
    Blast Score: 82
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00155
    Location:395475
    Blast Score: 354
    UBQ; Ubiquitin-like proteins

RNA

  1. XR_427469.1 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    924040..936230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    952456..967132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)