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Prkcq protein kinase C, theta [ Mus musculus (house mouse) ]

Gene ID: 18761, updated on 11-Sep-2014
Official Symbol
Prkcqprovided by MGI
Official Full Name
protein kinase C, thetaprovided by MGI
Primary source
MGI:97601
Locus tag
RP23-291L24.1
See related
Ensembl:ENSMUSG00000026778; Vega:OTTMUSG00000011317
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkcq; PKC-0; AW494342; PKCtheta; PKC-theta; A130035A12Rik
See Prkcq in Epigenomics, MapViewer
Location:
2 A1; 2 8.42 cM
Exon count:
19
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 2 NC_000068.7 (11171904..11301226)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene zinc finger and BTB domain containing 2 pseudogene Neighboring gene uncharacterized LOC102634279 Neighboring gene RIKEN cDNA 8030442B05 gene Neighboring gene predicted gene 13293

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of T cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISA
Inferred from Sequence Alignment
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T-helper 17 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T-helper 2 cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-2 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
protein kinase C theta type
Names
protein kinase C theta type
PKC theta
nPKC-theta
NP_032885.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008859.2NP_032885.1  protein kinase C theta type

    See proteins identical to NP_032885.1

    Status: PROVISIONAL

    Source sequence(s)
    AL928715, AL929020
    Consensus CDS
    CCDS15682.1
    UniProtKB/TrEMBL
    A6H667
    UniProtKB/Swiss-Prot
    Q02111
    Related
    ENSMUSP00000028118, OTTMUSP00000012133, ENSMUST00000028118, OTTMUST00000026520
    Conserved Domains (4) summary
    cd05619
    Location:384699
    Blast Score: 1806
    STKc_nPKC_theta; Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C theta
    smart00220
    Location:380634
    Blast Score: 791
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:232281
    Blast Score: 184
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl14603
    Location:22116
    Blast Score: 93
    C2; C2 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000068.7 

    Range
    11171904..11301226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497398.1XP_006497461.1  

    Conserved Domains (4) summary
    cd05619
    Location:341656
    Blast Score: 1799
    STKc_nPKC_theta; Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C theta
    smart00220
    Location:337591
    Blast Score: 787
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:189238
    Blast Score: 185
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl14603
    Location:873
    Blast Score: 89
    C2; C2 domain
  2. XM_006497399.1XP_006497462.1  

    See proteins identical to XP_006497462.1

    UniProtKB/TrEMBL
    Q920N8
    Conserved Domains (3) summary
    cd05619
    Location:141456
    Blast Score: 1790
    STKc_nPKC_theta; Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C theta
    smart00220
    Location:137391
    Blast Score: 785
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl00040
    Location:1738
    Blast Score: 81
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

Alternate Mm_Celera

Genomic

  1. AC_000024.1 

    Range
    11093754..11222740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)