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    CIZ1 CDKN1A interacting zinc finger protein 1 [ Homo sapiens (human) ]

    Gene ID: 25792, updated on 12-Jun-2016
    Official Symbol
    CIZ1provided by HGNC
    Official Full Name
    CDKN1A interacting zinc finger protein 1provided by HGNC
    Primary source
    HGNC:HGNC:16744
    See related
    Ensembl:ENSG00000148337 HPRD:13061; MIM:611420; Vega:OTTHUMG00000020735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NP94; LSFR1; ZNF356
    Summary
    The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
    Orthologs
    Location:
    9q34.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (128166065..128204383, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130928344..130966662, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene lipocalin 2 Neighboring gene chromosome 9 open reading frame 16 Neighboring gene dynamin 1 Neighboring gene microRNA 199b Neighboring gene microRNA 3154

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cip1-interacting zinc finger protein
    Names
    nuclear protein NP94
    zinc finger protein 356

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032983.1 RefSeqGene

      Range
      5001..43319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001131015.1NP_001124487.1  cip1-interacting zinc finger protein isoform 2

      See identical proteins and their annotated locations for NP_001124487.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate exon in place of the first exon, lacks an alternate in-frame exon, and lacks an alternate in-frame segment compared to variant 6. The resulting isoform (2) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 5.
      Source sequence(s)
      AK023978, BC004119, BC021163
      Consensus CDS
      CCDS48034.1
      UniProtKB/Swiss-Prot
      Q9ULV3
      UniProtKB/TrEMBL
      Q9BTG3
      Related
      ENSP00000362039, OTTHUMP00000022241, ENST00000372948, OTTHUMT00000054397
      Conserved Domains (4) summary
      smart00451
      Location:536565
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:610661
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      pfam12171
      Location:630654
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      sd00020
      Location:600620
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_001131016.1NP_001124488.1  cip1-interacting zinc finger protein isoform 1

      See identical proteins and their annotated locations for NP_001124488.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate exon in place of the first exon and lacks an alternate in-frame exon compared to variant 6. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 5. Variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AK292713, AK303636, BC021163, BM743935
      Consensus CDS
      CCDS6894.1
      UniProtKB/Swiss-Prot
      Q9ULV3
      UniProtKB/TrEMBL
      A0A024R885
      Related
      ENSP00000362029, OTTHUMP00000022243, ENST00000372938, OTTHUMT00000054399
      Conserved Domains (4) summary
      smart00451
      Location:592621
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:666717
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      pfam12171
      Location:686710
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      sd00020
      Location:656676
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. NM_001131017.1NP_001124489.1  cip1-interacting zinc finger protein isoform 3

      See identical proteins and their annotated locations for NP_001124489.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate exon in place of the first exon, lacks an alternate in-frame exon, and lacks an alternate in-frame segment compared to variant 6. The resulting isoform (3) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 5.
      Source sequence(s)
      AK303288, BC021163, BM757318
      UniProtKB/Swiss-Prot
      Q9ULV3
      UniProtKB/TrEMBL
      B4E0A3
      Conserved Domains (4) summary
      smart00451
      Location:531560
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:605656
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      pfam12171
      Location:625649
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      sd00020
      Location:595615
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. NM_001131018.1NP_001124490.1  cip1-interacting zinc finger protein isoform 4

      See identical proteins and their annotated locations for NP_001124490.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate exon in place of the first exon, lacks two alternate in-frame exons, and lacks an alternate in-frame segment compared to variant 6. The resulting isoform (4) is shorter at the N-terminus and lacks three alternate internal segments compared to isoform 5.
      Source sequence(s)
      BC021163, BM757318
      Consensus CDS
      CCDS48033.1
      UniProtKB/Swiss-Prot
      Q9ULV3
      Related
      ENSP00000362045, OTTHUMP00000022242, ENST00000372954, OTTHUMT00000054398
      Conserved Domains (4) summary
      smart00451
      Location:512541
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:586637
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      pfam12171
      Location:606630
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      sd00020
      Location:576596
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. NM_001257975.1NP_001244904.1  cip1-interacting zinc finger protein isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents the longest transcript. The resulting isoform (5) may be the longest isoform; however, the N-terminus of this isoform is only predicted and not supported by experimental data.
      Source sequence(s)
      AK296363, AL590708, BC021163
      Consensus CDS
      CCDS75910.1
      UniProtKB/Swiss-Prot
      Q9ULV3
      UniProtKB/TrEMBL
      B7Z3U7, F5H2X7
      Related
      ENSP00000439244, ENST00000538431
      Conserved Domains (2) summary
      smart00451
      Location:622651
      ZnF_U1; U1-like zinc finger
      pfam12171
      Location:742766
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    6. NM_001257976.1NP_001244905.1  cip1-interacting zinc finger protein isoform 6

      See identical proteins and their annotated locations for NP_001244905.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has an alternate exon in place of the first exon, lacks an alternate in-frame exon, and lacks another alternate exon compared to variant 6, that causes a frameshift. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 5.
      Source sequence(s)
      AK303636, AL590708, BC021163, BM742088
      Consensus CDS
      CCDS59147.1
      UniProtKB/Swiss-Prot
      Q9ULV3
      Related
      ENSP00000486816, OTTHUMP00000279132, ENST00000629610, OTTHUMT00000483935
      Conserved Domains (4) summary
      smart00451
      Location:491520
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:565616
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      pfam12171
      Location:585609
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      sd00020
      Location:555575
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. NM_012127.2NP_036259.2  cip1-interacting zinc finger protein isoform 1

      See identical proteins and their annotated locations for NP_036259.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has an alternate exon in place of the first exon and lacks an alternate in-frame exon compared to variant 6. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 5. Variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AF159025, AK023978, BC021163
      Consensus CDS
      CCDS6894.1
      UniProtKB/Swiss-Prot
      Q9ULV3
      UniProtKB/TrEMBL
      A0A024R885
      Related
      ENSP00000489425, OTTHUMP00000281537, ENST00000634901, OTTHUMT00000488609
      Conserved Domains (4) summary
      smart00451
      Location:592621
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:666717
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      pfam12171
      Location:686710
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      sd00020
      Location:656676
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      128166065..128204383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014594.1XP_016870083.1  

    2. XM_005251892.3XP_005251949.2  

      See identical proteins and their annotated locations for XP_005251949.2

      Conserved Domains (4) summary
      smart00451
      Location:531560
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:605656
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      pfam12171
      Location:625649
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      sd00020
      Location:595615
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. XM_011518481.1XP_011516783.1  

      Conserved Domains (4) summary
      smart00451
      Location:587616
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:661712
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      pfam12171
      Location:681705
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      sd00020
      Location:651671
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_005251891.3XP_005251948.2  

      See identical proteins and their annotated locations for XP_005251948.2

      UniProtKB/Swiss-Prot
      Q9ULV3
      Related
      ENSP00000277465, OTTHUMP00000022245, ENST00000277465, OTTHUMT00000054401
      Conserved Domains (4) summary
      smart00451
      Location:536565
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:610661
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      pfam12171
      Location:630654
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      sd00020
      Location:600620
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. XM_005251888.3XP_005251945.2  

      See identical proteins and their annotated locations for XP_005251945.2

      UniProtKB/Swiss-Prot
      Q9ULV3
      UniProtKB/TrEMBL
      A0A024R885
      Conserved Domains (4) summary
      smart00451
      Location:592621
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:666717
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      pfam12171
      Location:686710
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      sd00020
      Location:656676
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. XM_006717039.3XP_006717102.2  

      Related
      ENSP00000398011, OTTHUMP00000022246, ENST00000415526, OTTHUMT00000054402
    7. XM_005251893.4XP_005251950.4  

    8. XM_011518482.2XP_011516784.2  

    9. XM_011518483.1XP_011516785.1  

      Conserved Domains (4) summary
      smart00451
      Location:568597
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:642693
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      pfam12171
      Location:662686
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      sd00020
      Location:632652
      ZF_C2H2; C2H2 Zn finger [structural motif]
    10. XM_017014595.1XP_016870084.1  

    11. XM_017014596.1XP_016870085.1  

      Related
      ENSP00000350169, ENST00000357558

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      131079359..131117686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)