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    Rag1 recombination activating gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 19373, updated on 26-Jun-2016
    Official Symbol
    Rag1provided by MGI
    Official Full Name
    recombination activating gene 1provided by MGI
    Primary source
    MGI:MGI:97848
    See related
    Ensembl:ENSMUSG00000061311 Vega:OTTMUSG00000014584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rag-1
    Orthologs
    Location:
    2 E2; 2 53.88 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (101638252..101649532, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (101478409..101489689, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA B230118H07 gene Neighboring gene predicted gene, 39887 Neighboring gene recombination activating gene 2 Neighboring gene predicted gene, 34041 Neighboring gene TNF receptor-associated factor 6

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • Primary immunodeficiency, organism-specific biosystem (from KEGG)
      Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Primary immunodeficiency, conserved biosystem (from KEGG)
      Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    T/G mismatch-specific endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    coenzyme F420-0 gamma-glutamyl ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    coenzyme F420-2 alpha-glutamyl ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metal ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoric ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity, elongating IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity, initiating IEA
    Inferred from Electronic Annotation
    more info
     
    retroviral 3' processing activity IEA
    Inferred from Electronic Annotation
    more info
     
    ribosomal S6-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    tubulin-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tubulin-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    B cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    DNA recombination TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    T cell homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    V(D)J recombination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    V(D)J recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    V(D)J recombination ISO
    Inferred from Sequence Orthology
    more info
     
    adaptive immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    histone monoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of thymocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    pre-B cell allelic exclusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pre-B cell allelic exclusion ISO
    Inferred from Sequence Orthology
    more info
     
    protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of T cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    thymus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    V(D)J recombination-activating protein 1
    Names
    recombinase activating gene 1
    recombination activating protein 1
    recombination-activating gene 1
    NP_033045.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009019.2NP_033045.2  V(D)J recombination-activating protein 1

      See identical proteins and their annotated locations for NP_033045.2

      Status: VALIDATED

      Source sequence(s)
      AK162974, AL929569
      Consensus CDS
      CCDS16463.1
      UniProtKB/Swiss-Prot
      P15919
      UniProtKB/TrEMBL
      Q3TR87
      Related
      ENSMUSP00000077584, OTTMUSP00000015477, ENSMUST00000078494, OTTMUST00000034580
      Conserved Domains (3) summary
      pfam10426
      Location:351380
      zf-RAG1; Recombination-activating protein 1 zinc-finger domain
      pfam12940
      Location:510950
      RAG1; Recombination-activation protein 1 (RAG1)
      cd00162
      Location:290332
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      101638252..101649532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499012.1XP_006499075.1  

      See identical proteins and their annotated locations for XP_006499075.1

      UniProtKB/Swiss-Prot
      P15919
      Conserved Domains (3) summary
      pfam10426
      Location:351380
      zf-RAG1; Recombination-activating protein 1 zinc-finger domain
      pfam12940
      Location:510950
      RAG1; Recombination-activation protein 1 (RAG1)
      cd00162
      Location:290332
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...