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    Trpc6 transient receptor potential cation channel, subfamily C, member 6 [ Mus musculus (house mouse) ]

    Gene ID: 22068, updated on 3-Jul-2016
    Official Symbol
    Trpc6provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily C, member 6provided by MGI
    Primary source
    MGI:MGI:109523
    See related
    Ensembl:ENSMUSG00000031997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRP-6; Trrp6; mtrp6; AV025995; LLHWJM002; LLHWJM003; LLHWJM004
    Orthologs
    Location:
    9 A1; 9 2.46 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (8543931..8680752)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (8544142..8680741)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene U1-snRNP binding protein homolog pseudogene Neighboring gene microRNA 1899 Neighboring gene predicted gene, 32014 Neighboring gene progesterone receptor Neighboring gene Rho GTPase activating protein 42 Neighboring gene predicted gene, 16833

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    inositol 1,4,5 trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    store-operated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    manganese ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    slit diaphragm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    short transient receptor potential channel 6
    Names
    calcium entry channel
    transient receptor protein 6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282086.1NP_001269015.1  short transient receptor potential channel 6 isoform 2

      See identical proteins and their annotated locations for NP_001269015.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC155906, AC156791, AK133864, BC067391
      UniProtKB/TrEMBL
      Q3UZG1, Q6NV56
      Conserved Domains (3) summary
      cd00204
      Location:104238
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08344
      Location:252314
      TRP_2; Transient receptor ion channel II
      TIGR00870
      Location:81818
      trp; transient-receptor-potential calcium channel protein
    2. NM_001282087.1NP_001269016.1  short transient receptor potential channel 6 isoform 3

      See identical proteins and their annotated locations for NP_001269016.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC155906, BC067391
      UniProtKB/TrEMBL
      Q6NV56
      Conserved Domains (4) summary
      cd00204
      Location:104238
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08344
      Location:252314
      TRP_2; Transient receptor ion channel II
      pfam12796
      Location:136244
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:103152
      Ank_4; Ankyrin repeats (many copies)
    3. NM_013838.2NP_038866.2  short transient receptor potential channel 6 isoform 1

      See identical proteins and their annotated locations for NP_038866.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC155906, AC156791, AK133864, AK137447
      Consensus CDS
      CCDS22815.1
      UniProtKB/Swiss-Prot
      Q61143
      UniProtKB/TrEMBL
      Q3UZG1
      Related
      ENSMUSP00000057965, ENSMUST00000050433
      Conserved Domains (3) summary
      cd00204
      Location:104238
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08344
      Location:252314
      TRP_2; Transient receptor ion channel II
      TIGR00870
      Location:81896
      trp; transient-receptor-potential calcium channel protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      8543931..8680752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509850.3XP_006509913.1  

      See identical proteins and their annotated locations for XP_006509913.1

      UniProtKB/Swiss-Prot
      Q61143
      Conserved Domains (3) summary
      cd00204
      Location:104238
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08344
      Location:252314
      TRP_2; Transient receptor ion channel II
      TIGR00870
      Location:81896
      trp; transient-receptor-potential calcium channel protein
    2. XM_011242359.2XP_011240661.1  

      Conserved Domains (4) summary
      cd00204
      Location:104238
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08344
      Location:252314
      TRP_2; Transient receptor ion channel II
      cl12057
      Location:794889
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
      TIGR00870
      Location:81868
      trp; transient-receptor-potential calcium channel protein
    3. XM_011242360.2XP_011240662.1  

      See identical proteins and their annotated locations for XP_011240662.1

      UniProtKB/TrEMBL
      Q3UZG1
      Conserved Domains (3) summary
      cd00204
      Location:104238
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08344
      Location:252314
      TRP_2; Transient receptor ion channel II
      TIGR00870
      Location:81818
      trp; transient-receptor-potential calcium channel protein
    4. XM_006509849.3XP_006509912.1  

      Conserved Domains (3) summary
      cd00204
      Location:123257
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08344
      Location:271333
      TRP_2; Transient receptor ion channel II
      TIGR00870
      Location:100915
      trp; transient-receptor-potential calcium channel protein