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Foxp3 forkhead box P3 [ Mus musculus (house mouse) ]

Gene ID: 20371, updated on 8-Jul-2014
Official Symbol
Foxp3provided by MGI
Official Full Name
forkhead box P3provided by MGI
Primary source
MGI:1891436
Locus tag
RP23-54C14.1
See related
Ensembl:ENSMUSG00000039521; Vega:OTTMUSG00000016624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sf; JM2; scurfin
See Foxp3 in Epigenomics, MapViewer
Location:
X A1.1; X 3.41 cM
Exon count :
15
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) X NC_000086.7 (7579676..7595243)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene kelch-like 21 pseudogene Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 3F Neighboring gene protein phosphatase 1, regulatory subunit 3F, opposite strand Neighboring gene coiled-coil domain containing 22 Neighboring gene calcium channel, voltage-dependent, alpha 1F subunit Neighboring gene synaptophysin Neighboring gene predicted gene 14703

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
    Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding, bending IBA
Inferred from Biological aspect of Ancestor
more info
 
NFAT protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
NFAT protein binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
histone acetyltransferase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell activation ISO
Inferred from Sequence Orthology
more info
 
T cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo development IBA
Inferred from Biological aspect of Ancestor
more info
 
immunoglobulin V(D)J recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
lung development IBA
Inferred from Biological aspect of Ancestor
more info
 
myeloid cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of CREB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of CREB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of chronic inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of chronic inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytokine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of cytokine secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of histone deacetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of immune response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interferon-gamma biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-2 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-2 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-2 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-4 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-5 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-5 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of isotype switching to IgE isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell anergy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell tolerance induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 
positive regulation of histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of immunoglobulin production IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of peripheral T cell tolerance induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of regulatory T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transforming growth factor beta1 production IDA
Inferred from Direct Assay
more info
PubMed 
pre-B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of isotype switching to IgG isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulatory T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
tolerance induction IDA
Inferred from Direct Assay
more info
PubMed 
tolerance induction to self antigen IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
forkhead box protein P3
Names
forkhead box protein P3
scurfy

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199347.1NP_001186276.1  forkhead box protein P3

    See proteins identical to NP_001186276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF277992, AL672231, AL731793
    Consensus CDS
    CCDS29965.1
    UniProtKB/TrEMBL
    Q53Z59
    UniProtKB/Swiss-Prot
    Q99JB6
    Related
    ENSMUSP00000111405, OTTMUSP00000017952, ENSMUST00000115740, OTTMUST00000040205
    Conserved Domains (1) summary
    cd00059
    Location:337409
    Blast Score: 307
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA ...
  2. NM_001199348.1NP_001186277.1  forkhead box protein P3

    See proteins identical to NP_001186277.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF277991, AL672231
    Consensus CDS
    CCDS29965.1
    UniProtKB/TrEMBL
    Q53Z59
    UniProtKB/Swiss-Prot
    Q99JB6
    Related
    ENSMUSP00000111403, OTTMUSP00000017962, ENSMUST00000115738, OTTMUST00000040222
    Conserved Domains (1) summary
    cd00059
    Location:337409
    Blast Score: 307
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA ...
  3. NM_054039.2NP_473380.1  forkhead box protein P3

    See proteins identical to NP_473380.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF277992, AL672231, AL731793
    Consensus CDS
    CCDS29965.1
    UniProtKB/TrEMBL
    Q53Z59
    UniProtKB/Swiss-Prot
    Q99JB6
    Related
    ENSMUSP00000111404, OTTMUSP00000017961, ENSMUST00000115739, OTTMUST00000040221
    Conserved Domains (1) summary
    cd00059
    Location:337409
    Blast Score: 307
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000086.7 

    Range
    7579676..7595243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000042.1 

    Range
    3876528..3892094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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