Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Pcyt1a phosphate cytidylyltransferase 1, choline, alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140544, updated on 8-Aug-2016
    Official Symbol
    Pcyt1aprovided by RGD
    Official Full Name
    phosphate cytidylyltransferase 1, choline, alphaprovided by RGD
    Primary source
    RGD:70515
    See related
    Ensembl:ENSRNOG00000001762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CTP; CCT-alpha
    Summary
    catalyzes rate-limiting synthesis of phosphotidylcholine; plays a key role in cell membrane synthesis and in supply of lipid second messenger [RGD, Feb 2006]
    Orthologs
    Location:
    11q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (71547865..71592037, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (74632576..74676227, complement)

    Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC-type containing 19 Neighboring gene solute carrier family 51, alpha subunit Neighboring gene Tctex1 domain containing 2 Neighboring gene transmembrane 4 L six family member 19

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC93248

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    choline-phosphate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphatidylcholine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    CDP-choline pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylcholine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylcholine biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    glycogen granule IEA
    Inferred from Electronic Annotation
    more info
     
    glycogen granule ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    choline-phosphate cytidylyltransferase A
    Names
    CCT A
    CT A
    CTP:phosphocholine cytidylyl transferase
    CTP:phosphocholine cytidylyltransferase A
    CTP:phosphocholine cytidylyltransferase alpha
    choline phosphate cytidylyltransferase 1 alpha
    phosphate cytidylyltransferase 1, choline, alpha isoform
    phosphorylcholine transferase A
    NP_511177.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_078622.2NP_511177.2  choline-phosphate cytidylyltransferase A

      See identical proteins and their annotated locations for NP_511177.2

      Status: VALIDATED

      Source sequence(s)
      AW919077, BF285251, BQ780519, L13245
      UniProtKB/Swiss-Prot
      P19836
      Related
      ENSRNOP00000002403, ENSRNOT00000002403
      Conserved Domains (1) summary
      cd02174
      Location:75224
      CCT; CTP:phosphocholine cytidylyltransferase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

      Range
      71547865..71592037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768694.2XP_008766916.1  

      See identical proteins and their annotated locations for XP_008766916.1

      UniProtKB/Swiss-Prot
      P19836
      Conserved Domains (1) summary
      cd02174
      Location:75224
      CCT; CTP:phosphocholine cytidylyltransferase
    2. XM_006248444.3XP_006248506.1  

      See identical proteins and their annotated locations for XP_006248506.1

      UniProtKB/Swiss-Prot
      P19836
      Conserved Domains (1) summary
      cd02174
      Location:75224
      CCT; CTP:phosphocholine cytidylyltransferase

    Alternate Rn_Celera

    Genomic

    1. AC_000079.1 Alternate Rn_Celera

      Range
      67749599..67789957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)